1-Isobutyl-2-methylimidazole CAS 116680-33-2

Introduction：Basic information about 1-Isobutyl-2-methylimidazole CAS 116680-33-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

1-Isobutyl-2-methylimidazole Basic information

• Product Name: 1-Isobutyl-2-methylimidazole
• Synonyms: 1H-IMidazole,2-Methyl-1-(2-Methylpropyl)- (Related Reference);1H-IMidazole,2-Methyl-1-(2-Methylpropyl)-;1-Isobutyl-2-MethyliMidazole;1-isobutyl-2-methyl-1H-imidazole;2-Methyl-1-(2-methylpropyl)-1H-imidazole;1H-IMidazole,2-Methy;1H-IMidazole,2-Methyl-1-(2-Methylpropyl)- (Related Reference) Factory;N-isobutyl-2-methylimidazole
• CAS: 116680-33-2
• MF: C8H14N2
• MW: 138.21
• Mol File: 116680-33-2.mol

1-Isobutyl-2-methylimidazole Chemical Properties

• Boiling point: 225-256 °C
• density: 0.94±0.1 g/cm3(Predicted)
• pka: 7.80±0.31(Predicted)
• InChI: InChI=1S/C8H14N2/c1-7(2)6-10-5-4-9-8(10)3/h4-5,7H,6H2,1-3H3
• InChIKey: SVNWKKJQEFIURY-UHFFFAOYSA-N
• SMILES: C1(C)N(CC(C)C)C=CN=1

1-Isobutyl-2-methylimidazole Usage And Synthesis

Application

1-Isobutyl-2-methylimidazole is an important coating additive and pharmaceutical intermediate, which can be obtained by nucleophilic substitution of 2-methylimidazole and chloroisobutane.

Description

1-Isobutyl-2-methylimidazole is an important coating additive and pharmaceutical intermediate. This compound is mainly prepared from 2-methylimidazole and iodoalkane as raw materials.

Synthesis

In 100 ml of toluene add 25 ml of triethylamine, add 12.3 g of 2-methylimidazole, heating to 60 ~ 65 ?? C, dissolved clear at this temperature slowly added 16.7 g of chlorinated isobutane dropwise, dropwise completion of the 60 ~ 65 ?? C holding time of 3 hours, 3 hours after a slow increase in temperature to 100 ~ 110 ?? C, and then held at this temperature for 5 hours, holding time completion of the cooled to 10 ?? C or less, filtration , the filtrate was distilled and 13 g of 96-98??C (4.5 mmHg) fraction was collected as 1-isobutyl-2-methylimidazole. The molar yield of the method was 63% in terms of 2-methylimidazole.