2-(4-Chlorophenoxy)-2-methylpropionic acid CAS 882-09-7
2-(4-Chlorophenoxy)-2-methylpropionic acid Basic information
| Product Name: | 2-(4-Chlorophenoxy)-2-methylpropionic acid |
| Synonyms: | CLOFIBRIC ACID;4-Chorophenoxy-d-methylpropionicacid;4-CPIB;Chlorobenzene oxygenisobutyrate;Acetic acid, (p-chlorop;Prestwick_39;2-(4-Chlorophe;Acetic acid, (p-chlorophenoxy)dimethyl- |
| CAS: | 882-09-7 |
| MF: | C10H11ClO3 |
| MW: | 214.65 |
| EINECS: | 212-925-9 |
| Product Categories: | Organic acids;Aromatics Compounds;Intracellular receptor;Acids and Derivatives;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;CLOFIBRIN;882-09-7 |
| Mol File: | 882-09-7.mol |
2-(4-Chlorophenoxy)-2-methylpropionic acid Chemical Properties
| Melting point | 120-122 °C(lit.) |
| Boiling point | 308.11°C (rough estimate) |
| density | 1.2413 (rough estimate) |
| refractive index | 1.5220 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol |
| pka | 3.18±0.10(Predicted) |
| form | Crystals or Crystalline Powder |
| color | Pale yellow to brownish |
| Merck | 14,2378 |
| BRN | 1874067 |
| InChI | 1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13) |
| InChIKey | TXCGAZHTZHNUAI-UHFFFAOYSA-N |
| SMILES | CC(C)(Oc1ccc(Cl)cc1)C(O)=O |
| CAS DataBase Reference | 882-09-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Clofibric acid(882-09-7) |
| EPA Substance Registry System | Propanoic acid, 2-(4-chlorophenoxy)-2-methyl- (882-09-7) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-20/21/22 |
| Safety Statements | 36-24/25 |
| WGK Germany | 3 |
| RTECS | UE9455000 |
| HazardClass | IRRITANT |
| HS Code | 29189900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Description | Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 μM in a transactivation assay) and the active metabolite of clofibrate . It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 μg/L. Clofibric acid has been found in wastewater effluent. |
| Chemical Properties | Pale Yellow Solid |
| Uses | Antilipemic. |
| Uses | herbicide, antihyperlipoproteinemic, antineoplastic |
| Uses | A hypolipidemic compound |
| Definition | ChEBI: A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate. |
| Biological Activity | PPAR agonist. Antihyperlipoproteinemic. |
| Synthesis | 637-07-0 882-09-7 Step 2: Synthesis of 2-(4-chlorophenoxy)-2-methylpropionic acidTo a solution of ethyl 2-(4-chlorophenoxy)-2-methylpropionate (2.0 g, 8.24 mmol) in tetrahydrofuran (16 mL) was added sequentially water (4 mL) and lithium hydroxide monohydrate (0.69 g, 16.4 mmol) at room temperature. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the mixture was diluted with water and washed with dichloromethane (DCM). The aqueous phase was separated and acidified with 1 M aqueous hydrochloric acid to pH about 2, followed by extraction with dichloromethane (DCM, 2 times). The organic extracts were combined, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 2-(4-chlorophenoxy)-2-methylpropionic acid (p-chlorophenoxyisobutyric acid) as a white solid (1.45 g, 82% yield).1H NMR (400 MHz, chloroform-d): δ 1.62 (6H, s), 6.89 (2H, d, J = 9.0 Hz), 7.24 (2H, d, J = 9.0 Hz). |
| References | [1] Journal of Medicinal Chemistry, 2017, vol. 60, # 2, p. 681 - 694 [2] Patent: WO2009/105509, 2009, A1. Location in patent: Page/Page column 36-37 [3] Journal of Pharmaceutical Sciences, 1980, vol. 69, # 1, p. 92 - 93 [4] Patent: WO2008/104994, 2008, A2. Location in patent: Page/Page column 32-33 [5] Patent: US2009/197959, 2009, A1. Location in patent: Page/Page column 18 |
2-(4-Chlorophenoxy)-2-methylpropionic acid Preparation Products And Raw materials
| Raw materials | O-(4-chlorophenyl)hydroxylamine-->plafibride-->Chlorobutanol-->4-CHLOROPHENOL SODIUM SALT-->N-Acetyl-L-cysteine-->4-Chlorophenol-->Ethyl 2-bromoisobutyrate-->Acetone-->Chloroform-->Acetamide |
| Preparation Products | Clofibrate-->etofibrate 2-hydroxymethylnicotinate-->Nicotinic acid |
