Introduction：Basic information about 2-(Hydroxymethyl)pyridine CAS 586-98-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-(Hydroxymethyl)pyridine Basic information
| Product Name: | 2-(Hydroxymethyl)pyridine |
| Synonyms: | 2-Pyridine methanol(2-hydromethyl pyridine);2-HYDROXYMETHYLPYRIDINE(PYRIDINE-2-CARBINOL);2-Pyridinemethanol,ω-Hydroxy-2-picoline, 2-(Hydroxymethyl)pyridine, 2-Pyridyl carbinol;2-(Hydroxymethyl)pyr;2-HYDROXYMETHYL PYRIDINE PYRIDIN-2-YL-METHANOL;PYRIDINE-2-METHANOL (2-PYRIDYLCARBINOL);2-Pyridine Methanol 99%;ω-Hydroxy-2-picoline, 2-(Hydroxymethyl)pyridine, 2-Pyridyl carbinol |
| CAS: | 586-98-1 |
| MF: | C6H7NO |
| MW: | 109.13 |
| EINECS: | 209-592-7 |
| Product Categories: | Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Pyridines;Pyridine;bc0001;C6 |
| Mol File: | 586-98-1.mol |
|
2-(Hydroxymethyl)pyridine Chemical Properties
| Melting point | 5 °C |
| Boiling point | 112-113 °C/16 mmHg (lit.) |
| density | 1.131 g/mL at 25 °C (lit.) |
| vapor pressure | 3.47Pa at 25℃ |
| refractive index | n20/D 1.543(lit.) |
| Fp | >230 °F |
| storage temp. | 2-8°C |
| solubility | miscible |
| form | Liquid |
| pka | 13.48±0.10(Predicted) |
| color | Clear colorless to yellow or brown |
| Specific Gravity | 1.131 |
| Odor | pyridine odor |
| PH | 6-8 (100g/l, H2O, 20℃) |
| Water Solubility | miscible |
| Sensitive | Hygroscopic |
| BRN | 107849 |
| InChI | 1S/C6H7NO/c8-5-6-3-1-2-4-7-6/h1-4,8H,5H2 |
| InChIKey | SHNUBALDGXWUJI-UHFFFAOYSA-N |
| SMILES | OCc1ccccn1 |
| LogP | 0.11 |
| CAS DataBase Reference | 586-98-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Piconol(586-98-1) |
Safety Information
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-22 |
| Safety Statements | 26-36-37/39 |
| WGK Germany | 3 |
| RTECS | UT4689000 |
| F | 3-8 |
| Hazard Note | Irritant/Keep Cold/Hygroscopic |
| HazardClass | IRRITANT, HYGROSCOPIC, KEEP COLD |
| HS Code | 29333999 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
2-(Hydroxymethyl)pyridine Usage And Synthesis
| Chemical Properties | CLEAR COLORLESS TO YELLOW OR BROWN LIQUID |
| Uses | decongestant |
| Uses | A pyridylalcohol with hypoglycemic activity and potential apoptotic effect in human leukemia cells. |
| Uses | 2-Pyridinemethanol is used as a pyridylalcohol with hypoglycemic activity. |
| Preparation | The preparation of 2-(Hydroxymethyl)pyridine is as follows:NaOH (0.5 g, 12.5 mmol), Al2O3 (2.0 g, 19.6 mmol), aldehyde 1f-g (2 mmol) and H2O (400 μL) were grinded in a mortar. Next, the paste were placed in a glass 10 mL pressure vials and reaction was carried out in microwave reactor: standard mode (200 W), 100 °C, 2 min. After that, reaction mixture was extracted with DCM (2 × 20 mL). Organic layer was evaporated under reduce pressure yielding 2f-g. Solid residue was washed by water (2 × 15 mL). Aqueous phase was acidify with 1N HCl to pH 5.5 and centrifuged. After that aqueous layer was pour down and precipitate was lyophilisated. Products 3f-g were obtained as white solids. |
| Definition | ChEBI: 2-Pyridinylmethanol is a member of pyridines. |
2-(Hydroxymethyl)pyridine Preparation Products And Raw materials
| Raw materials | Methanol-->4-Pyridylcarbinol-->2-Cyanopyridine |
| Preparation Products | 2-Chloro-5-hydroxymethylpyridine-->2-(2-Pyridyl)benzoxazole-->Methyl picolinate-->Ethyl picolinate-->2-(Bromomethyl)pyridine-->1-PYRIDIN-2-YLMETHYL-PIPERAZINE-->2,2'-DIPICOLYLAMINE-->2-(2-PYRIDYL)BENZIMIDAZOLE |
