Introduction：Basic information about 2-(Trimethylsilyl)pyridine CAS 13737-04-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-(Trimethylsilyl)pyridine Basic information
| Product Name: | 2-(Trimethylsilyl)pyridine |
| Synonyms: | 2-(TRIMETHYLSILYL)PYRIDINE;2-(TRIMETHYLSILYL)PYRIDINE, PURUM, 98%;2-Trimethylsilanyl-pyridine;Pyridine,2-(trimethylsilyl)-;2-(Trimethysilyl)pyridine;2-TRIMETHYLSILY-PYRIDINE;2-(TRIMETHYLSILYL)PYRIDINE, 97+%;2-pyridyltrimethylsilane |
| CAS: | 13737-04-7 |
| MF: | C8H13NSi |
| MW: | 151.28 |
| EINECS: | |
| Product Categories: | Si (Classes of Silicon Compounds);Si-(C)4 Compounds;C7 and C8;Heterocyclic Building Blocks;Pyridines |
| Mol File: | 13737-04-7.mol |
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2-(Trimethylsilyl)pyridine Chemical Properties
| Boiling point | 47-49 °C5 mm Hg(lit.) |
| density | 0.9113 g/mL at 25 °C(lit.) |
| refractive index | n20/D 1.489(lit.) |
| Fp | 126 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 6.62±0.10(Predicted) |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Specific Gravity | 0.911 |
| Sensitive | Light Sensitive |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| InChI | InChI=1S/C8H13NSi/c1-10(2,3)8-6-4-5-7-9-8/h4-7H,1-3H3 |
| InChIKey | IBLKFJNZUSUTPB-UHFFFAOYSA-N |
| SMILES | C1([Si](C)(C)C)=NC=CC=C1 |
| CAS DataBase Reference | 13737-04-7(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 10-36/37/38 |
| Safety Statements | 16-26-36-37/39 |
| RIDADR | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| HazardClass | 3 |
| PackingGroup | III |
| HS Code | 29333990 |
2-(Trimethylsilyl)pyridine Usage And Synthesis
| Uses | 2-Trimethylsilylpyridine is a pyridine derivative that can be used as an intermediate in organic synthesis. |
| Chemical Properties | Clear colorless to brown liquid |
| Synthesis | A solution of 2-chloropyridine (20.7 mL, 217 mmol) and trimethylchlorosilane (28.0 mL, 221 mmol) in THF (100 mL) was added dropwise to a rapidly stirred mixture of magnesium chips (6.75 g, 281 mmol) in THF (175 mL).The solution in was added dropwise to a rapidly stirred mixture of magnesium shavings (6.75 g, 281 mmol) in THF (175 mL). After adding approximately 10 mL of solution was followed by the addition of diiodomethane (0.2 mL), then iodine pellets, and then isopropylmagnesium chloride (2.0 M THF solution, 1 mL, 2 mmol). The suspension was then carefully heated to reflux and the remaining chloride solution was added dropwise over 2.75 hours. The reaction was then allowed to cool to room temperature and stirred overnight. Approximately 200 mL of was removed by distillation of theTHF and benzene (125mL) was added. The suspension was refluxed for 2 hours and the benzene was decanted. The benzene was then removed by adding more benzene (2 x 125 mL), refluxing (1 each time) and decanting.hours) and decanting the process was repeated and the combined benzene fractions were concentrated in vacuum and distilled to give 2-trimethylsilylpyridine (6.97 g, 46.2 mmol , 21%) in colorless liquid form. |
2-(Trimethylsilyl)pyridine Preparation Products And Raw materials
| Raw materials | Trimethyl(3-pyridyl)silane-->4-(Trimethylsilyl)pyridine-->2-Bromopyridine-->2-Chloropyridine-->Pyridine-->Chlorotrimethylsilane |
| Preparation Products | Methyl picolinate-->2-(methylsulfonyl)pyridine-->HEXYL PICOLINATE |
