Introduction：Basic information about 2,3,4-Trihydroxybenzaldehyde CAS 2144-08-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2,3,4-Trihydroxybenzaldehyde Basic information
| Product Name: | 2,3,4-Trihydroxybenzaldehyde |
| Synonyms: | 2,3,4-TrihydroxybenzaL;2,3,4-TRIHYDROXYBENZALDEHYDE;2,3,4-Trihydroxybenzaldehyde,98%;2,3,4-TRIHYDROXYBENZALDEHYDE 98%;PYROGALLOLALDEHYDE;PYROGALLOL-4-CARBOXALDEHYDE;2,3,4-Trihydroxybenazldehyde;2,3,4-THB |
| CAS: | 2144-08-3 |
| MF: | C7H6O4 |
| MW: | 154.12 |
| EINECS: | 218-404-2 |
| Product Categories: | Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;2144-08-3 |
| Mol File: | 2144-08-3.mol |
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2,3,4-Trihydroxybenzaldehyde Chemical Properties
| Melting point | 159-161 °C (lit.) |
| Boiling point | 237.46°C (rough estimate) |
| density | 1.3725 (rough estimate) |
| refractive index | 1.6400 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol |
| pka | 7.41±0.23(Predicted) |
| form | Powder |
| color | Light brown to beige-brown |
| Water Solubility | 1.541g/L at 25℃ |
| Sensitive | Air Sensitive |
| BRN | 2328658 |
| InChI | 1S/C7H6O4/c8-3-4-1-2-5(9)7(11)6(4)10/h1-3,9-11H |
| InChIKey | CRPNQSVBEWWHIJ-UHFFFAOYSA-N |
| SMILES | [H]C(=O)c1ccc(O)c(O)c1O |
| LogP | 1.25 |
| CAS DataBase Reference | 2144-08-3(CAS DataBase Reference) |
| EPA Substance Registry System | Benzaldehyde, 2,3,4-trihydroxy- (2144-08-3) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39-36 |
| WGK Germany | 2 |
| RTECS | CU8439800 |
| TSCA | TSCA listed |
| HS Code | 29124990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
2,3,4-Trihydroxybenzaldehyde Usage And Synthesis
| Description | 2,3, 4-trihydroxybenzaldehyde is an essential intermediate of the antiparkinson drug benserazide, which is a peripheral dopa decarboxylase inhibitor, usually benserazide: the L-dopa is prepared into a compound preparation at a ratio of 1:4, and has a remarkable effect of treating the Parkinson's disease. |
| Chemical Properties | light brown to beige-brown powder |
| Uses | 2,3,4-Trihydroxybenzaldehyde is a phenolic benzaldehyde with antibacterial activity. |
| Uses | 2,3,4-Trihydroxybenzaldehyde has been used in the preparation of 1,5-dimethyl-2-phenyl-4-[(1E)-(2,3,4-trihydroxybenzylidene)amino]-1H-pyrazol-3(2H)-one. |
| General Description | Antimicrobial activity of carbohydrazone derived from 2,3,4-trihydroxybenzaldehyde against bacteria and fungi has been investigated. 2,3,4-trihydroxybenzaldehyde forms Schiff bases via [1+1] condensation with anthranilic acid. |
| Synthesis | The method for synthesizing 2,3, 4-trihydroxybenzaldehyde is shown as follows.
This method takes pyrogallol as an initial raw material. It comprises three steps of phenolic hydroxyl protection, formylation, and deprotection: protecting two adjacent phenolic hydroxyl groups in the pyrogallol to obtain 4-hydroxybenzo[d][1,3]dioxol-2-one, then performing formylation to obtain 7-hydroxy-2-oxobenzo[d][1,3]dioxole-4-carbaldehyde, and finally removing a protecting group to get a target 2,3,4-trihydroxybenzaldehyde.
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2,3,4-Trihydroxybenzaldehyde Preparation Products And Raw materials
| Raw materials | Gallic acid |
| Preparation Products | 7,8-Dihydroxycoumarin-->Licochalcone B |
