Introduction：Basic information about 2-bromo-4-chloropropiophenone CAS 877-37-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-bromo-4-chloropropiophenone Basic information
| Product Name: | 2-bromo-4-chloropropiophenone |
| Synonyms: | 2-bromo-4-chloropropiophenone;2-Bromo-1-(4-chloro-phenyl)-propan-1-one, 2-Бром-1-(4-хлорфенил)-пропан-1-он, 2-bromo-4'-chloropropiophenone;1-Propanone, 2-bromo-1-(4-chlorophenyl)-;2-Bromo-1-(4-chlorophenyl)-1-propanone;Bupropion Impurity 32;(2R)-2-bromo-1-(4-chlorophenyl)propan-1-one;BCPP;2-bromo-4 '-chloroacetone |
| CAS: | 877-37-2 |
| MF: | C9H8BrClO |
| MW: | 247.52 |
| EINECS: | 100-413-0 |
| Product Categories: | |
| Mol File: | 877-37-2.mol |
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2-bromo-4-chloropropiophenone Chemical Properties
| Melting point | 77-79 °C(Solv: ligroine (8032-32-4)) |
| Boiling point | 296.7±15.0 °C(Predicted) |
| density | 1.518±0.06 g/cm3(Predicted) |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Off-White to Pale Beige |
| InChI | InChI=1S/C9H8BrClO/c1-6(10)9(12)7-2-4-8(11)5-3-7/h2-6H,1H3 |
| InChIKey | SAKMPXRILWVZEG-UHFFFAOYSA-N |
| SMILES | C(C1=CC=C(Cl)C=C1)(=O)C(Br)C |
Safety Information
2-bromo-4-chloropropiophenone Usage And Synthesis
| Uses | 2-bromo-4-chloropropiophenone can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and chemical production processes. |
| Application | 2-bromo-4-chloropropiophenone is an analytical reference standard categorized as a precursor in the synthesis of cathinones, including 4-chlorocathinone, 4-chloro-N, N-dimethylcathinone, 4-chloro-N-isopropylcathinone, 4-chloro-N-butylcathinone, 4-chloroethcathinone, and 4'-chloro-α-pyrrolidinopropiophenone. 2-Bromo-4'-chloropropiophenone is also a precursor in the synthesis of 4-chloromethcathinone. |
| Synthesis | A solution of 15.9 g (0.1 mol) of bromine in 20 ml of chloroform is added dropwise to a solution of 16.8 g (0.1 mol) of 4'-chloropropiophenone in 100 ml of chloroform, in the presence of a small amount of aluminium chloride, and the mixture is stirred overnight. After filtration and evaporation of the filtrate, the crystalline residue is washed with petroleum ether. When dry, it melts at 75° C. |
2-bromo-4-chloropropiophenone Preparation Products And Raw materials
| Raw materials | 4'-Chloropropiophenone-->Chlorobenzene-->2-Bromopropionyl bromide |
