Introduction：Basic information about 2-Bromo-5-chlorobenzotrifluoride CAS 344-65-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-Bromo-5-chlorobenzotrifluoride Basic information
| Product Name: | 2-Bromo-5-chlorobenzotrifluoride |
| Synonyms: | Benzene,2-bromo-5-chloro-1-(trifluoromethyl)-;2-bromo-5-chloro-α,α,α-trifluorotoluene;2-Bromo-5-chlorobenzotrifluoride 99%;2-Bromo-5-chlorobenzotrifluoride99%;2-BROMO-5-CHLOROBENZOTRIFLUORIDE, 98+%;1-Bromo-4-chloro-2-(trifluoromethyl)benzene;2-Bromo-5-chlorobenzotrifluoride,2-Bromo-5-chloro-α,α,α-trifluorotoluene;2-BroMo-5-chlorozotrifluoride |
| CAS: | 344-65-0 |
| MF: | C7H3BrClF3 |
| MW: | 259.45 |
| EINECS: | 608-994-3 |
| Product Categories: | Bromine Compounds;Chlorine Compounds;Fluorine Compounds |
| Mol File: | 344-65-0.mol |
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2-Bromo-5-chlorobenzotrifluoride Chemical Properties
| Melting point | 18-20°C |
| Boiling point | 179-180 °C (lit.) |
| density | 1.759 g/mL at 25 °C (lit.) |
| refractive index | n20/D 1.5080(lit.) |
| Fp | 198°C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | clear liquid |
| color | Colorless to Almost colorless |
| BRN | 2448030 |
| InChI | 1S/C7H3BrClF3/c8-6-2-1-4(9)3-5(6)7(10,11)12/h1-3H |
| InChIKey | OSTIALFVJOFNPP-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1cc(Cl)ccc1Br |
| CAS DataBase Reference | 344-65-0(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39-36-37-23 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HS Code | 29039990 |
| Storage Class | 10 - Combustible liquids |
2-Bromo-5-chlorobenzotrifluoride Usage And Synthesis
| Chemical Properties | Clear colourless to slightly yellow liquid |
| Uses | 2-Bromo-5-chlorobenzotrifluoride was used in preparation of 6-[4-chloro-2-(trifluoromethyl)phenyl]-3-fluoro-2-methylpyridine and 4,4′-dichloro-2,2′-bis(trifluoromethyl) diphenyl sulphone. |
| Synthesis | 393-36-2 344-65-0 The general procedure for synthesizing 2-bromo-5-chlorobenzotrifluoride from 5-amino-2-bromobenzotrifluoride was as follows: a diazonium salt solution was prepared according to the method described in Example 3. The cooled diazonium salt solution was slowly added to a pre-stirred and cooled mixture of CuCl (8.9 g, 0.091 mol) dissolved in concentrated hydrochloric acid (46 g, 0.44 mol). The reaction system was kept at a low temperature and when the addition was completed, it was gradually warmed up to room temperature with continuous stirring for 2 to 3 hours. Subsequently, the reaction mixture was heated to 60-70 °C to ensure complete reaction. Upon completion of the reaction, the target product 2-bromo-5-chlorobenzotrifluoride was obtained by isolation by appropriate methods. Yield: 65%. |
| References | [1] Patent: WO2016/63300, 2016, A1. Location in patent: Page/Page column 8
[2] Journal of the American Chemical Society, 1953, vol. 75, p. 3034 |
2-Bromo-5-chlorobenzotrifluoride Preparation Products And Raw materials
| Raw materials | 4-Bromo-3-(trifluoromethyl)aniline-->Sodium nitrite-->Hydrochloric acid-->Copper(I) chloride |
| Preparation Products | 4-Chloro-4-methyl-2-(trifluoromethyl)-1,1-biphenyl |
