Introduction：Basic information about 2-Hydroxy-2-methylpropiophenone CAS 7473-98-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-Hydroxy-2-methylpropiophenone Basic information
| Product Name: | 2-Hydroxy-2-methylpropiophenone |
| Synonyms: | Photocure-1173;1-Phenyl-2-Hydroxy-2-Methyl-1-Propanone;2-Hydroxy-2-Methylpheny-Propane-1-one;1-Propanone, 2-hydroxy-2-methyl-1-phenyl-;ACETOCURE 73;1-Phenyl-2-hydroxy-2-methylpropane-1-one;1-Phenyl-2-methyl-2-hydroxy-1-propanone;2-Hydroxy-2-methyl-1-phenylpropane-1-one |
| CAS: | 7473-98-5 |
| MF: | C10H12O2 |
| MW: | 164.2 |
| EINECS: | 231-272-0 |
| Product Categories: | Other Products;Functional Materials;Photopolymerization Initiators;Acetophenone;Organic Photoinitiators;Polymerization Initiators;Industrial/Fine Chemicals;Additives for Plastic;Pharmaceutical Intermediates |
| Mol File: | 7473-98-5.mol |
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2-Hydroxy-2-methylpropiophenone Chemical Properties
| Melting point | 4°C |
| Boiling point | 102-103 °C4 mm Hg(lit.) |
| density | 1.077 g/mL at 25 °C(lit.) |
| vapor pressure | 0.57Pa at 20℃ |
| refractive index | n20/D 1.533(lit.) |
| Fp | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Practically insoluble in water |
| form | clear liquid |
| pka | 13.23±0.29(Predicted) |
| color | Colorless to Light orange to Yellow |
| Specific Gravity | 1.077 |
| Odor | Slight odor |
| Water Solubility | 13.3g/L at 20℃ |
| Cosmetics Ingredients Functions | FILM FORMING |
| InChI | 1S/C10H12O2/c1-10(2,12)9(11)8-6-4-3-5-7-8/h3-7,12H,1-2H3 |
| InChIKey | XMLYCEVDHLAQEL-UHFFFAOYSA-N |
| SMILES | CC(C)(O)C(=O)c1ccccc1 |
| LogP | 1.62 at 25℃ |
| CAS DataBase Reference | 7473-98-5(CAS DataBase Reference) |
| EPA Substance Registry System | 1-Propanone, 2-hydroxy-2-methyl-1-phenyl- (7473-98-5) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 23-36/37/39 |
| RIDADR | 3082 |
| WGK Germany | 3 |
| RTECS | UC2977245 |
| TSCA | TSCA listed |
| HazardClass | 9 |
| PackingGroup | III |
| HS Code | 29144000 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Acute Tox. 4 Oral
Aquatic Chronic 3 |
2-Hydroxy-2-methylpropiophenone Usage And Synthesis
| Uses | 2-Hydroxy-2-methylpropiophenone is a photoinitiator.In addition, 2-hydroxy-2-methylpropiophenone is an important organic intermediate (building block) to synthetize substituted propiophenone products. |
| Chemical Properties | Yellowish clear liquid |
| Uses | 2-Hydroxy-2-benzoylpropane was used as a catalyst in real-time kinetic study of laser-induced polymerization. It is also a photoinitiator. |
| Synthesis Reference(s) | Tetrahedron Letters, 29, p. 4365, 1988 DOI: 10.1016/S0040-4039(00)80496-7 |
| General Description | 2-Hydroxy-2-methylpropiophenone is a radical photoinitiator (PI) molecule that can be used in the crosslinking of polymers by the exposure of UV radiation. It can be used in the development of UV curable resins for exterior coating applications. |
| Hazard | Moderately toxic by ingestion. |
| Flammability and Explosibility | Not classified |
| Synthesis | KBr in water is added to a solution of 2-methyl-1-phenylpropane-1,2-diol in toluene. Then, TEMPO is added. The reddish suspension is cooled to 0°C. A 12 % sodium hypochlorite solution is added while maintaining the internal temperature at 5°C or lower. The mixture is stirred for 1 h at 0-5°C and then separated for 10 min. Sodium dithionite solution (obtained from 30 g sodium dithionite (85%) and 400 ml of water)is added to the organic phase and stirred at 85°C for 1-2 h. The organic phase is again separated and concentrated (rotavap). The crude product is then subjected to fractional distillation, yielding 2-Hydroxy-2-methylpropiophenone as a colorless oil.
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| Toxics Screening Level | The ITSL for 2-hydroxy-2-methyl-1-phenyl-1-propanone has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on annual averaging time. |
2-Hydroxy-2-methylpropiophenone Preparation Products And Raw materials
| Raw materials | 1,2-Propanediol,2-methyl-1-phenyl--->2-chloro-2-methylpropiophenone-->Isobutyrophenone |
