Introduction：Basic information about 3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione CAS 2300099-98-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione Basic information
| Product Name: | 3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione |
| Synonyms: | 2,6-Piperidinedione, 3-(5-bromo-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-;3-(5-bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione;3-(5-bromo-3-methyl-2-oxo-benzimidazol-1-yl)piperidine-2,6-dione;3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1-benzimidazolyl)piperidine-2,6-dione;3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)piperidine-2,6-dione;3-(5-Bromo-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-2,6-piperidinedione (ACI);3-(5-BROMO-3-METHYL-2-OXO-2,3-DIHYDRO-1H-BENZODIMIDAZOL-1-YL)PIPERIDINE-2;E3 ligase Ligand 32 |
| CAS: | 2300099-98-1 |
| MF: | C13H12BrN3O3 |
| MW: | 338.16 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 2300099-98-1.mol |
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3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione Chemical Properties
| Boiling point | 533.3±50.0 °C(Predicted) |
| density | 1.670±0.06 g/cm3(Predicted) |
| storage temp. | Storage temp. 2-8°C |
| form | Solid |
| pka | 11.11±0.40(Predicted) |
| color | Off-white to light brown |
| InChI | InChI=1S/C13H12BrN3O3/c1-16-10-6-7(14)2-3-8(10)17(13(16)20)9-4-5-11(18)15-12(9)19/h2-3,6,9H,4-5H2,1H3,(H,15,18,19) |
| InChIKey | JTRNEHBIODAOTJ-UHFFFAOYSA-N |
| SMILES | N1C(=O)CCC(N2C(=O)N(C)C3=CC(Br)=CC=C32)C1=O |
Safety Information
3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione Usage And Synthesis
| Uses | E3 ligase Ligand 32 (First product in Example 52) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743)[1]. |
| IC 50 | VHL |
| References | [1] Nan Ji, et al. Smarca degraders and uses thereof. Worldwide applications 2020 US WO |
3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione Preparation Products And Raw materials
