Introduction：Basic information about 3,6-DIHYDROXYXANTHONE CAS 529-61-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
3,6-DIHYDROXYXANTHONE Basic information
| Product Name: | 3,6-DIHYDROXYXANTHONE |
| Synonyms: | 3,6-DIHYDROXYXANTHONE;1,7-DIHYDROXYXANTHONE;1,7-Dihydroxy-9H-xanthen-9-one;Eyxanthone;9H-Xanthen-9-one, 1,7-dihydroxy-;IFLAB-BB F0349-4255 |
| CAS: | 529-61-3 |
| MF: | C13H8O4 |
| MW: | 228.2 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 529-61-3.mol |
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3,6-DIHYDROXYXANTHONE Chemical Properties
| storage temp. | 2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | powder |
| color | Yellow |
Safety Information
3,6-DIHYDROXYXANTHONE Usage And Synthesis
| Uses | Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3]. |
| Definition | ChEBI: A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1 and 7 and an oxo group at position 9. It has been isolated from Cratoxylum cochinchinense. |
| Synthesis Reference(s) | Synthetic Communications, 19, p. 1641, 1989 DOI: 10.1080/00397918908051061 |
| in vivo | Euxanthone (40-80 mg/kg) could significantly decrease the number of metastatic nodules in lung tissue in a pulmonary metastasis model[1].
Euxanthone (30-60 mg/kg; p.o.;once a day; for 7 days) treatment normalized Bnip3, Beclin1, Pink1, Parkin, p53, Bax, caspase-3, and LC3 II/I in bearing bilateral common carotid artery occlusion (BCCAO). Euxanthone modulates mitophagy and apoptosis induces by mitochondrial stress mediated by mitochondrial fragmentation[2]. | Animal Model: | Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion[2] | | Dosage: | 30 mg/kg, 60 mg/kg | | Administration: | p.o.;once a day; for 7 days | | Result: | Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown. |
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| References | [1] Xiaodong Chen, et al. Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression. Anat Rec (Hoboken). 2019 Aug;302(8):1399-1408. DOI:10.1002/ar.23992
[2] Wei Sun, et al. Euxanthone improves cognitive impairment by attenuating mitochondrial fragmentation and suppressing oxidative stress. Cent Eur J Immunol. 2021;46(4):446-455. DOI:10.5114/ceji.2021.111444
[3] aicheng Yuan, et al. Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy. J Mol Neurosci. 2018 Dec;66(4):512-523. DOI:10.1007/s12031-018-1175-2 |
3,6-DIHYDROXYXANTHONE Preparation Products And Raw materials
| Raw materials | Methanone, (2,5-dihydroxyphenyl)(2,6-dihydroxyphenyl)--->9H-Xanthen-9-one, 7-hydroxy-1-methoxy--->GENTISEIN-->1,7-Dimethoxyxanthone-->METHYL 3,5-DIHYDROXYBENZOATE-->Water-->Sulfuric acid-->Aluminum chloride-->2,5-Dihydroxybenzoic acid-->2,4-Dihydroxybenzoic acid-->Toluene-->Hydroquinone-->Resorcinol |
| Preparation Products | 1,5-Dihydroxyxanthone-->Emodin |
