Introduction：Basic information about 3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANAL CAS 89922-82-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANAL Basic information
| Product Name: | 3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANAL |
| Synonyms: | 3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANAL;3-(TERT-BUTYL-DIMETHYL-SILANYLOXY)-PROPIONALDEHYDE;3-Tert-butyldiMethylsilyloxy)propionaldehyde;3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]propanal;Propanal,3-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-;3-(tert-Butyldimethylsiloxy)propionaldehyde;3-[Dimethyl(1,1-dimethylethyl)siloxy]propanal;3-TBDMSO-propionaldehyde |
| CAS: | 89922-82-7 |
| MF: | C9H20O2Si |
| MW: | 188.34 |
| EINECS: | |
| Product Categories: | Miscellaneous Reagents |
| Mol File: | 89922-82-7.mol |
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3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANAL Chemical Properties
| Boiling point | 95 °C(Press: 23 Torr) |
| density | 0.892 g/mL at 25 °C |
| refractive index | n20/D1.431 |
| Fp | 84℃ |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Oil |
| color | Colourless to Pale Yellow |
| InChI | InChI=1S/C9H20O2Si/c1-9(2,3)12(4,5)11-8-6-7-10/h7H,6,8H2,1-5H3 |
| InChIKey | WGWCJTNWUFFGFH-UHFFFAOYSA-N |
| SMILES | C(=O)CCO[Si](C(C)(C)C)(C)C |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | WGK 3 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANAL Usage And Synthesis
| Chemical Properties | Brown Oil |
| Uses | 3-[(tert-Butyldimethylsilyl)oxy]-1-propanal is useful for preparing EGFR inhibitors for the treatment of cancer. |
| Preparation | 3-(tert-Butyldimethylsilyloxy)propanol (1.90 g, 10 mmol) was dissolved in dichloromethane (20 mL), and Dess-Martin reagent (6.36 g, 15 mmol) was added under ice bath. After stirring at room temperature for 4 hours, saturated aqueous sodium bicarbonate solution was added to quench, and the mixture was diluted with dichloromethane (100 mL). The mixture was washed twice with saturated aqueous sodium bicarbonate solution and once with brine. The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo. The mixture was purified by silica gel column chromatography to obtain 1.55 g of 3-[(tert-Butyldimethylsilyl)oxy]-1-propanal with a yield of 82%.
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| Chemical Reactivity | 3-[(tert-Butyldimethylsilyl)oxy]-1-propanal is stable under normal conditions, it reacts with oxidizing agents. |
3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANAL Preparation Products And Raw materials
| Raw materials | BUT-3-ENYLOXY-TERT-BUTYL-DIMETHYL-SILANE-->3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]Propanenitrile-->methyl 3-[tert-butyl(dimethyl)silyl]oxypropanoate-->3-(T-BUTYLDIMETHYLSILOXY)PROPANOL-->TERT-BUTYLDIMETHYL(2-PROPYNYLOXY)SILANE-->TETRAPROPYLAMMONIUM PERRUTHENATE-->Diethyl ether-->tert-Butyldimethylsilyl chloride-->1,3-Propanediol-->Sodium bicarbonate |
