3-BENZYLOXYANILINE CAS 1484-26-0
3-BENZYLOXYANILINE Basic information
| Product Name: | 3-BENZYLOXYANILINE |
| Synonyms: | Benzenamine, 3-(phenylmethoxy)-;M-(BENZYLOXY)ANILINE;3-BENZYLOXYANILINE;AKOS BBB/398;AKOS BC-2549;TIMTEC-BB SBB000388;3-Aminophenyl benzyl ether;3-Benzyloxyaniline 98% |
| CAS: | 1484-26-0 |
| MF: | C13H13NO |
| MW: | 199.25 |
| EINECS: | 216-056-6 |
| Product Categories: | Anilines, Aromatic Amines and Nitro Compounds;Amines;C11 to C38;Nitrogen Compounds |
| Mol File: | 1484-26-0.mol |
3-BENZYLOXYANILINE Chemical Properties
| Melting point | 63-67 °C (lit.) |
| Boiling point | 170 °C(Press: 3 Torr) |
| density | 1.129±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| pka | 4.17±0.10(Predicted) |
| form | Solid |
| color | Pale brown |
| InChI | InChI=1S/C13H13NO/c14-12-7-4-8-13(9-12)15-10-11-5-2-1-3-6-11/h1-9H,10,14H2 |
| InChIKey | IGPFOKFDBICQMC-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=CC(OCC2=CC=CC=C2)=C1 |
| CAS DataBase Reference | 1484-26-0(CAS DataBase Reference) |
| EPA Substance Registry System | 3-(Benzyloxy)aniline (1484-26-0) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29222990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| Chemical Properties | Beige to tan powder |
| Synthesis Reference(s) | Tetrahedron Letters, 23, p. 147, 1982 DOI: 10.1016/S0040-4039(00)86770-2 |
| Synthesis | 24318-00-1 1484-26-0 591-27-5 Using 1-(benzyloxy)-3-nitrobenzene as the starting material, the reaction was carried out using an experimental method similar to that of Example 59, in which ferrous acetate (II), nickel nitrate (II), or cobalt acetylacetonate (III) was chosen as the metal reducing agent. The experimental results are detailed in Table 11. The data of Examples 60 to 66 show that the reaction rate is significantly enhanced when metal compounds such as iron, nickel or cobalt salts and amine additives such as pyrrolidine are added to the catalytic reduction system of the present invention in the presence of a rhodium/carrier catalyst. Under this condition, functional groups such as benzyl ether, which are easy to reduce, are retained, and nitro is selectively reduced to amino, thereby increasing the yield of the target products 3-benzyloxyaniline and 3-aminophenol. |
| References | [1] Patent: EP1541582, 2005, A1. Location in patent: Page/Page column 45 [2] Patent: EP1541582, 2005, A1. Location in patent: Page/Page column 45 [3] Patent: EP1541582, 2005, A1. Location in patent: Page/Page column 45 [4] Patent: EP1541582, 2005, A1. Location in patent: Page/Page column 45 [5] Patent: EP1541582, 2005, A1. Location in patent: Page/Page column 45 |
3-BENZYLOXYANILINE Preparation Products And Raw materials
| Raw materials | Tetrahydrofuran-->Potassium carbonate-->Acetone-->Hydrogen-->Benzyl chloride-->4-Nitrophenol-->Rhodium-->Ferrous acetate-->1-(BENZYLOXY)-3-NITROBENZENE-->Pyrrolidine |
| Preparation Products | 3-(Benzyloxy)-N-methylaniline |
