Introduction：Basic information about 3-Fluorophenylhydrazine hydrochloride CAS 2924-16-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
3-Fluorophenylhydrazine hydrochloride Basic information
| Product Name: | 3-Fluorophenylhydrazine hydrochloride |
| Synonyms: | 3-FLUOROPHENYLHYDRAZINE HYDROCHLORIDE;1-(3-FLUOROPHENYL)HYDRAZINE HYDROCHLORIDE;3-FLUOROPHENYLHYDRAZINE HYDROCHLORIDE, 9 7%;3-Fluorophenylhydrazine HCl;3-Fluorophenylhydrazine hydrochloride 97%;3-FluorPhenylhydrazine hydrochloride;Hydrazine, (3-fluorophenyl)-, monohydrochloride;Hydrazine, (3-fluorophenyl)-, hydrochloride (1:1) |
| CAS: | 2924-16-5 |
| MF: | C6H8ClFN2 |
| MW: | 162.59 |
| EINECS: | 220-886-4 |
| Product Categories: | Aryl Fluorinated Building Blocks;Building Blocks;C6;Chemical Synthesis;Fluorinated Building Blocks;Nitrogen Compounds;Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Phenylhydrazine;Hydrazines;Nitrogen Compounds;Organic Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks |
| Mol File: | 2924-16-5.mol |
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3-Fluorophenylhydrazine hydrochloride Chemical Properties
| Melting point | 268 °C (dec.)(lit.) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform : DMSO = 1 : 1 (Slightly), Methanol (Slightly) |
| form | Powder |
| color | White to light brown |
| BRN | 3627729 |
| InChI | InChI=1S/C6H7FN2.ClH/c7-5-2-1-3-6(4-5)9-8;/h1-4,9H,8H2;1H |
| InChIKey | SKVGLOFWEJFQKU-UHFFFAOYSA-N |
| SMILES | C1(NN)=CC=CC(F)=C1.Cl |
| CAS DataBase Reference | 2924-16-5(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xn,Xi,T |
| Risk Statements | 20/21/22-36/37/38-43-40-23/24/25 |
| Safety Statements | 26-37/39-45-36/37-36 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| PackingGroup | III |
| HS Code | 29280000 |
3-Fluorophenylhydrazine hydrochloride Usage And Synthesis
| Chemical Properties | white to light yellow crystal powde |
| Uses | 3-Fluorophenylhydrazine Hydrochloride can be used to synthesize compounds that are useful for the prophylaxis and treatment of pro-inflammatory cytokine mediated diseases, and in particular, p38 activity mediated inflammation and related conditions. |
| Synthesis | 658-27-5 2924-16-5 4) Saltation reaction: 22.1 g of (3-fluorophenyl)hydrazine was dissolved in 15.4 mL of 37% hydrochloric acid and stirred at 65 °C until crystals precipitated from the reaction solution. The reaction solution was then cooled to 20 °C and the solid product was collected by filtration. The filter cake was washed with acetone and dried to give 24.4 g of 3-fluorophenylhydrazine hydrochloride with 99.2% purity and 39.1% yield. |
| References | [1] Patent: CN106518716, 2017, A. Location in patent: Paragraph 0026 |
3-Fluorophenylhydrazine hydrochloride Preparation Products And Raw materials
| Raw materials | (3-FLUOROPHENYL)HYDRAZINE-->Hydrochloric acid-->Water |
| Preparation Products | 5-amino-1-(3-fluorophenyl)-1H-pyrazole-4-carbonitrile-->5-TERT-BUTYL-2-(3-FLUORO-PHENYL)-2H-PYRAZOL-3-YLAMINE |
