3-Furoic acid CAS 488-93-7
Introduction：Basic information about 3-Furoic acid CAS 488-93-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
3-Furoic acid Basic information
| Product Name: | 3-Furoic acid |
| Synonyms: | 3-Furoic AcidSynonyMs 3-Furancarboxylic acid;3-Furancarboxylic acid (9CI);RARECHEM AL BO 1157;TIMTEC-BB SBB004325;3-FUROIC ACID;3-FURANCARBOXYLIC ACID;FURAN-3-CARBOXYLIC ACID;3-FUROIC ACID 99% |
| CAS: | 488-93-7 |
| MF: | C5H4O3 |
| MW: | 112.08 |
| EINECS: | 207-689-9 |
| Product Categories: | Building Blocks;C4 to C7;Chemical Synthesis;Heterocyclic Building Blocks;Furans;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Furan&Benzofuran |
| Mol File: | 488-93-7.mol |
3-Furoic acid Chemical Properties
| Melting point | 120-122 °C (lit.) |
| Boiling point | 229.64°C |
| density | 1.3220 |
| refractive index | 1.4710 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 3.9(at 25℃) |
| form | Solid |
| color | Off-White to Beige |
| Water Solubility | insoluble |
| BRN | 108638 |
| InChI | 1S/C5H4O3/c6-5(7)4-1-2-8-3-4/h1-3H,(H,6,7) |
| InChIKey | IHCCAYCGZOLTEU-UHFFFAOYSA-N |
| SMILES | OC(=O)c1ccoc1 |
| LogP | 1.030 |
| CAS DataBase Reference | 488-93-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-Furancarboxylic acid(488-93-7) |
Safety Information
| Hazard Codes | Xi,C |
| Risk Statements | 36/37/38-34 |
| Safety Statements | 26-36/37-45-36/37/39-36 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29321900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 |
| Description | 3-Furoic acid, also known as 3-carboxyfuran or 3-furoate, belongs to the class of organic compounds known as furoic acids. These are organic compounds containing a furoic acid moiety, with a structure characterized by a furan ring bearing a carboxylic acid group at the C2 or C3 carbon atom. 3-Furoic acid is an organic acid regularly occurring in urine of healthy individuals. It is used in synthesis of furan-2,5- and furan-2,4-dicarboxylic acid under solvent-free conditions via disproportionation reaction. It exhibits hypolipidemic activity in rodents. It lowers serum cholesterol and serum triglyceride levels in mice and rats. |
| Chemical Properties | white to light yellow crystal powde |
| Uses | 3-Furoic acid can be used as a reactant to synthesize: Furan-2,5- and furan-2,4-dicarboxylic acid under solvent-free conditions via disproportionation reaction. (±)-Hyperolactone A by reacting with 2-methylbutanal. Furo[2,3-b]pyridin-4-one-5-carboxylate ester derivatives as potential non-nucleoside inhibitors of human herpesvirus polymerases. |
| Uses | 3-Furoic acid is used in synthesis of furan-2,5- and furan-2,4-dicarboxylic acid under solvent-free conditions via disproportionation reaction. It exhibits hypolipidemic activity in rodents. It lowers serum cholesterol and serum triglyceride levels in mice and rats. |
| Uses | 3-Furoic acid can be used as a reactant to synthesize:
|
| Definition | ChEBI: A furoic acid carrying the carboxy group at position 3. |
| Synthesis Reference(s) | Tetrahedron Letters, 26, p. 1509, 1985 DOI: 10.1016/S0040-4039(00)98538-1 |
| Biological Activity | 3-Furoic acid exhibits hypolipidemic activity in rodents. It lowers serum cholesterol and serum triglyceride levels in mice and rats. |
| Biochem/physiol Actions | 3-Furoic acid exhibits hypolipidemic activity in rodents. It lowers serum cholesterol and serum triglyceride levels in mice and rats. |
| Purification Methods | Crystallise the acid from water or aqueous EtOH, and sublime it in a vacuum. [Beilstein 18 I 439, 18 III/IV 4052, 18/6 V 196.] |
3-Furoic acid Preparation Products And Raw materials
| Raw materials | Hydrogen bromide-->Sodium ethoxide |
| Preparation Products | TETRAHYDRO-3-FUROIC ACID-->3-FURYLMETHYLAMINE-->3-(Chloromethyl)furan-->Telatinib-->Carbamic acid, 3-furanyl-, 1,1-dimethylethyl ester (9CI)-->TETRAHYDRO-FURAN-3-CARBONYL CHLORIDE-->2-Methyl-3-furoic Acid-d3-->3-Furancarboxylic acid, 5-acetyl--->ETHYL 6H-FURO[2,3-B]PYRROLE-5-CARBOXYLATE-->2-iodofuran-3-carboxylic acid-->1H-Benzimidazole,2-(3-furanyl)-(9CI)-->2-Bromo-3-furoyl chloride |
