Introduction：Basic information about 3-Quinuclidinol CAS 1619-34-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
3-Quinuclidinol Basic information
| Product Name: | 3-Quinuclidinol |
| Synonyms: | 3-Hydroxyxinyclidine;dl-3-Quinuclidinol;NSC 93905;1-Azabicyclo[2.2.2]octan-3-ol, 3-Hydroxyquinuclidine;QUINICLIDINE-3-OL;3-Quinuclidinol,99%;2-Amino-N-ethylbenze;Quinuclidin-3-ol, 1-Azabicyclo[2.2.2]octan-3-ol |
| CAS: | 1619-34-7 |
| MF: | C7H13NO |
| MW: | 127.18 |
| EINECS: | 216-578-4 |
| Product Categories: | Heterocycles;Intermediates & Fine Chemicals;Pharmaceutical material and intermeidates;Quinuclidine derivatives;Pharmaceuticals |
| Mol File: | 1619-34-7.mol |
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3-Quinuclidinol Chemical Properties
| Melting point | 220-223 °C(lit.) |
| Boiling point | 235.98°C (rough estimate) |
| density | 1.0083 (rough estimate) |
| refractive index | 1.4790 (estimate) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acidic (Slightly), Chloroform (Sparingly), Methanol (Slightly) |
| pka | 14.75±0.20(Predicted) |
| form | Crystalline Powder |
| color | White to beige |
| Water Solubility | soluble |
| Sensitive | Air Sensitive |
| Merck | 14,8082 |
| BRN | 104327 |
| LogP | 0.17 |
| CAS DataBase Reference | 1619-34-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-Quinuclidinol(1619-34-7) |
| EPA Substance Registry System | 1-Azabicyclo[2.2.2]octan-3-ol (1619-34-7) |
Safety Information
| Hazard Codes | C,F |
| Risk Statements | 34-11 |
| Safety Statements | 26-36/37/39-45-16 |
| RIDADR | UN 3263 8/PG 2 |
| WGK Germany | 3 |
| RTECS | VD6191700 |
| F | 34 |
| Hazard Note | Corrosive |
| TSCA | TSCA listed |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29333920 |
| Hazardous Substances Data | 1619-34-7(Hazardous Substances Data) |
3-Quinuclidinol Usage And Synthesis
| Chemical Properties | Crystalline Solid |
| Uses | Hypotensive. Synthon for preparation of cholinergic receptor ligands and anesthetics |
| Uses | 3-Quinuclidinol acts as a chiral building block for various antimuscarinic agents and other active pharmaceutical ingredients. It serves as a catalyst for condensation of methyl vinyl ketone with aldehydes. It is also used as a reagent for cleavage of beta-keto and vinylogous beta-keto esters. Further, it plays an important role as a synthon in the preparation of cholinergic receptor ligands and anesthetics. In addition to this, it is used in chemoselective alfa-iodination of acrylic esters through Morita-Baylis-Hillman reaction. |
| Definition | ChEBI: Quinuclidine in which a hydrogen atom at position 3 is substituted by a hydroxy group. |
| Hazard | Mutation. |
3-Quinuclidinol Preparation Products And Raw materials
