4-(Trifluoromethoxy)phenylhydrazine hydrochloride CAS 133115-72-7

Introduction：Basic information about 4-(Trifluoromethoxy)phenylhydrazine hydrochloride CAS 133115-72-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

4-(Trifluoromethoxy)phenylhydrazine hydrochloride Basic information

• Product Name: 4-(Trifluoromethoxy)phenylhydrazine hydrochloride
• Synonyms: p-trifluoromethoxy phenylhydrazine hydrochloride;(4-TRIFLUOROMETHOXYPHENYL)-HYDRAZINE HCL;TRIFLUOROMETHOXY)PHENYLHYDRAZINE HYDROCHLORIDE;4-(Trifluoromethoxy)phenylhydrazine hydrochloride 97%;4-(Trifluoromethoxy)phenylhydrazinehydrochloride97%;HYDRAZINE, [4-(TRIFLUOROMETHOXY)PHENYL]-, HYDROCHLORIDE;4-trifluoromethylbenzene hydrazind HCl;1-phenyl-1-(trifluoroMethoxy)hydrazine hydrochloride
• CAS: 133115-72-7
• MF: C7H8ClF3N2O
• MW: 228.6
• EINECS: 236-341-9
• Product Categories: Fluorine series;Hydrazines;Phenylhydrazine;Nitrogen Compounds;Organic Building Blocks
• Mol File: 133115-72-7.mol

4-(Trifluoromethoxy)phenylhydrazine hydrochloride Chemical Properties

• Melting point: 230 °C(lit.)
• storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Water Solubility: Soluble in water
• form: Powder
• color: White to pale brown
• InChI: InChI=1S/C7H7F3N2O.ClH/c8-7(9,10)13-6-3-1-5(12-11)2-4-6;/h1-4,12H,11H2;1H
• InChIKey: KQXZVSQCMVKMBK-UHFFFAOYSA-N
• SMILES: C1(OC(F)(F)F)C=CC(NN)=CC=1.Cl
• CAS DataBase Reference: 133115-72-7(CAS DataBase Reference)

Safety Information

• Hazard Codes: Xn,Xi
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• HS Code: 29280000
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

4-(Trifluoromethoxy)phenylhydrazine hydrochloride Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

4-(Trifluoromethoxy)phenylhydrazine hydrochloride may be used in the synthesis of pyrazole-containing bisphosphonate (N-BPs) esters.

General Description

4-(Trifluoromethoxy)phenylhydrazine hydrochloride is an organic building block.

Synthesis

A suspension of 4-trifluoromethoxyaniline (20 mmol) in water (65 mL) and concentrated HCl (25 mL) was cooled to 0-5 ??C. Sodium nitrite (1.55 g, 22 mmol) in water (15 ) was added dropwise to 4-trifluoromethoxyaniline (20 mmol) in water (65 mL) and concentrated HCl (25 mL).Sodium nitrite (1.55 g, 22 mmol) in water (15 mL) was added dropwise to a suspension of 4-trifluoromethoxyaniline (20 mmol) in water (65 mL) and concentrated HCl (25). mL) in water (65 mL) and concentrated HCl (25). The reaction mixture was stirred at 0-5 ??C for 45 min. A solution of SnCl2 (40 mmol) in concentrated HCl (10 mL) was added to the reaction mixture.solution of SnCl2 (40 mmol) is added to the reaction mixture. Allow the temperature to slowly increase until it reaches room temperature. Filter the suspension. Wash the remaining solid with saturated brine and ether. Suspend the solid in ether for a few minutes with stirring. Filter the solids. Dry the solids.