4,6-DIOXOHEPTANOIC ACID CAS 51568-18-4
Introduction：Basic information about 4,6-DIOXOHEPTANOIC ACID CAS 51568-18-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
4,6-DIOXOHEPTANOIC ACID Basic information
| Product Name: | 4,6-DIOXOHEPTANOIC ACID |
| Synonyms: | 4,6-DIOXOHEPTANOIC ACID;SUCCINYLACETONE;Succinylacetone-3,4,5,6,7-13C5;4,6-Dioxoheptanoic acid-3,4,5,6,7-13C5;[13C7]-Succinylacetone;Heptanoic acid, 4,6-dioxo-;4,6-dioxoheptanoicaci;4,6-Dioxoheptanoic acid (mixture of isomers) |
| CAS: | 51568-18-4 |
| MF: | C7H10O4 |
| MW: | 158.15 |
| EINECS: | |
| Product Categories: | Aliphatics;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 51568-18-4.mol |
4,6-DIOXOHEPTANOIC ACID Chemical Properties
| Melting point | 66-67 °C(lit.) |
| Boiling point | 318.7±17.0 °C(Predicted) |
| density | 1.189±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | powder |
| pka | 4.54±0.17(Predicted) |
| color | White to Off-White |
| Appearance | white solid |
| InChI | InChI=1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11) |
| InChIKey | WYEPBHZLDUPIOD-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CCC(=O)CC(=O)C |
| CAS DataBase Reference | 51568-18-4 |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Description | Succinylacetone (4,6-dioxoheptanoic acid), is a result of tyrosine metabolism disorder. The synthesis of this medium-chain keto acid in the body is due to the reduced activity of the enzyme fumarylacetoacetate hydrolase. Succinylacetone is an acidogen, its high concentrations can lead to metabolic acidosis, which leads to damage to the liver, kidneys, heart, and nervous system. Succinylacetone appears to be an oncometabolite because patients with high levels of this compound often develop hepatocellular carcinoma. Succinylacetone is widely used in research as an inhibitor of the enzyme 5-aminolevulinic acid dehydratase (ALAD), which plays a key role in heme biosynthesis. The product is used primarily as a control for MS/MS. |
| Chemical Properties | White Solid |
| Uses | 4,6-Dioxoheptanoic acid has been used:
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| Uses | Succinylacetone (SA) is a specific marker for the inherited metabolic disease, hepatorenal tyrosinemia. It was developed a stable-isotopequid urine using a 13C4-SA as internal standard. |
| Definition | ChEBI: A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia. |
| Biochem/physiol Actions | 4,6-Dioxoheptanoic acid is an inhibitor of heme biosynthesis. It is a catabolic byproduct of tyrosine breakdown and inhibits δ-aminolevulinic acid (ALA) dehydratase enzyme. It is a potential marker for detecting tyrosinemia type I and is measured in dried blood spot of new borns. |
| IC 50 | Human Endogenous Metabolite |
4,6-DIOXOHEPTANOIC ACID Preparation Products And Raw materials
