Introduction：Basic information about 4-[2-(2-Hydroxy-3,5-dimethylphenyl)-2-oxoethyl]piperidine-2,6-dione CAS 526-02-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
4-[2-(2-Hydroxy-3,5-dimethylphenyl)-2-oxoethyl]piperidine-2,6-dione Basic information
| Product Name: | 4-[2-(2-Hydroxy-3,5-dimethylphenyl)-2-oxoethyl]piperidine-2,6-dione |
| Synonyms: | 4-[2-(2-Hydroxy-3,5-dimethylphenyl)-2-oxoethyl]-2,6-piperidinedione;4-[2-(2-Hydroxy-3,5-dimethylphenyl)-2-oxoethyl]piperidine-2,6-dione;Actinophenol;Actiphenol;2,6-Piperidinedione, 4-[2-(2-hydroxy-3,5-dimethylphenyl)-2-oxoethyl]- |
| CAS: | 526-02-3 |
| MF: | C15H17NO4 |
| MW: | 275.3 |
| EINECS: | |
| Product Categories: | Antibiotic |
| Mol File: | 526-02-3.mol |
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4-[2-(2-Hydroxy-3,5-dimethylphenyl)-2-oxoethyl]piperidine-2,6-dione Chemical Properties
| Melting point | 200-202° |
| Boiling point | 498.7±40.0 °C(Predicted) |
| density | 1.232±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO; Soluble in Methanol |
| form | A solid |
| pka | 8.48±0.48(Predicted) |
Safety Information
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| HS Code | 29419000 |
4-[2-(2-Hydroxy-3,5-dimethylphenyl)-2-oxoethyl]piperidine-2,6-dione Usage And Synthesis
| Uses | Actiphenol is an antibiotic against coxsackievirus B3 and influenza A virus (IC50s = 14.37 and 34.4 μg/mL, respectively). Actiphenol is also an aromatic ketone that exhibits weak eukaryotic translation inhibiton activity, which is found in Streptomyces species. Actiphenol can be used as a key intermediate to synthesize Cycloheximide (HY-12320)[1][2]. |
| Definition | ChEBI: Actiphenol is an aromatic ketone. |
| References | [1] Ji XY, et al. Synthesis and antiviral activities of synthetic glutarimide derivatives. Chem Pharm Bull (Tokyo). 2010 Nov;58(11):1436-41. DOI:10.1248/cpb.58.1436
[2] Yin M, et al. Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. Org Lett. 2014 Jun 6;16(11):3072-5. DOI:10.1021/ol501179w |
4-[2-(2-Hydroxy-3,5-dimethylphenyl)-2-oxoethyl]piperidine-2,6-dione Preparation Products And Raw materials
