4-Benzyloxyphenylhydrazine CAS 51145-58-5

Introduction：Basic information about 4-Benzyloxyphenylhydrazine CAS 51145-58-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

4-Benzyloxyphenylhydrazine Basic information

• Product Name: 4-Benzyloxyphenylhydrazine
• Synonyms: 4-BENZYLOXYPHENYLHYDRAZINE;VITAS-BB TBB000092;Hydrazine, [4-(phenylmethoxy)phenyl]-;(4-Phenylmethoxyphenyl)hydrazine
• CAS: 51145-58-5
• MF: C13H14N2O
• MW: 214.26
• Product Categories: Miscellaneous;Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 51145-58-5.mol

4-Benzyloxyphenylhydrazine Usage And Synthesis

Uses

(4-Phenylmethoxyphenyl)hydrazine is used as a reactant in the preparation of indolyl thiazole derivatives as xanthine oxidase inhibitors and antiinflammatory drugs.

Manufacturing Process

Preparation of 4-benzyloxyphenylhydrazine: 200 grams 4-benzyloxyaniline hydrochloride was suspended in a mixture of 264 ml concentrated hydrochloric acid, 528 ml water and 732 grams crushed ice. A solution of 62.4 grams sodium nitrite in 136 ml water was added below the surface of the stirred suspension at -10-(+/-)2°C during 10 minutes. After stirring for 1 hour at 0°C, the suspension was treated with acid-washed charcoal and filtered.
The filtrate was cooled and maintained at -8°C while a solution of 500 grams of stannous chloride in 760 ml concentrated hydrochloric acid was added with stirring. The mixture was stirred for 2 hours at -8°C and the 4- benzyloxyphenylhydrazine hydrochloride which separated was filtered off and washed with water. The product was crystallized by adding 800 ml hot water to a 3 liter solution in ethanol and had a MP of 185° to 189°C (yield 168.5 grams, 79%).