Introduction：Basic information about 4-Hydroxyphenylacetamide CAS 17194-82-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
4-Hydroxyphenylacetamide Basic information
| Product Name: | 4-Hydroxyphenylacetamide |
| Synonyms: | 4-HYDROXYPHENYLACETAMIDE;4-HYDROXYBENZENEACETAMIDE;2-(4-HYDROXYPHENYL)ACETAMIDE;2-(4-HYDROXYPHENYL)-ETHYLAMIDE;4-HYDROXYPHENYLACETAMIDEATENOLOL;LABOTEST-BB LT00848172;ATENOLOL IMP A;ATENOLOL IMPURITY A |
| CAS: | 17194-82-0 |
| MF: | C8H9NO2 |
| MW: | 151.16 |
| EINECS: | 241-235-0 |
| Product Categories: | Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;pharmaceutical;Amides;Carbonyl Compounds;Organic Building Blocks |
| Mol File: | 17194-82-0.mol |
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4-Hydroxyphenylacetamide Chemical Properties
| Melting point | 176-178 °C (lit.) |
| Boiling point | 273.17°C (rough estimate) |
| density | 1.2023 (rough estimate) |
| refractive index | 1.5810 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Fine Crystalline Powder |
| pka | 9.99±0.26(Predicted) |
| color | Beige |
| Water Solubility | soluble |
| BRN | 2085984 |
| InChI | 1S/C8H9NO2/c9-8(11)5-6-1-3-7(10)4-2-6/h1-4,10H,5H2,(H2,9,11) |
| InChIKey | YBPAYPRLUDCSEY-UHFFFAOYSA-N |
| SMILES | NC(=O)Cc1ccc(O)cc1 |
| CAS DataBase Reference | 17194-82-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Hydroxyphenylacetamide(17194-82-0) |
| EPA Substance Registry System | Benzeneacetamide, 4-hydroxy- (17194-82-0) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25-37/39 |
| WGK Germany | 3 |
| RTECS | AC3851500 |
| Hazard Note | Irritant |
| TSCA | TSCA listed |
| HS Code | 29242990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
4-Hydroxyphenylacetamide Usage And Synthesis
| Chemical Properties | beige fine crystalline powder |
| Uses | 4-(Hydroxyphenyl)acetamide is used as an intermediate for the synthesis of Atenolol (A790075) and various other organic compounds and pharmaceuticals. It is a process impurity for Atenolol (A790075) |
| Uses | 4-(Hydroxyphenyl)acetamide (Atenolol EP Impurity A) is used as an intermediate for the synthesis of Atenolol (A790075) and various other organic compounds and pharmaceuticals. It is a process impurity for Atenolol (A790075) |
| Definition | ChEBI: 2-(4-Hydroxyphenyl)acetamide is a member of acetamides. |
4-Hydroxyphenylacetamide Preparation Products And Raw materials
| Raw materials | Glyoxal-->4-Chlorobenzyl cyanide-->4-Hydroxyphenylacetic acid-->Ammonium sulfide-->3'-Hydroxyacetophenone-->4-Hydroxybenzyl cyanide-->4-Aminophenylacetonitrile-->Phenol, 4-[2-(bromomethyl)-1,3-dioxolan-2-yl]--->Benzeneacetyl chloride, 4-hydroxy--->2-(4-HYDROXYPHENYL)ACETALDEHYDE-->p-Hydroxyphenyl propanoate-->3,5-Dibromo-L-tyrosine-->Methyl 4-hydroxyphenylacetate-->4-ACETOXYACETOPHENONE-->4'-Hydroxyacetophenone-->3,5-Diiodo-L-tyrosine dihydrate-->Methyl formate |
| Preparation Products | (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE |
