5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine CAS 6981-18-6

Introduction：Basic information about 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine CAS 6981-18-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Basic information

• Product Name: 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
• Synonyms: ORMETHOPRIM;ORMETOPRIM;ORMETOPRIN;OMP;5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine;L-Ascorbic Phosphate Magnesium;2,4-DiaMino-5-92-Methyl-4,5-diMethoxybenzyl)pyriMidine;DiaMino-5-(6-Methylveratryl)pyriMidine
• CAS: 6981-18-6
• MF: C14H18N4O2
• MW: 274.32
• EINECS: 230-246-6
• Product Categories: Active Pharmaceutical Ingredients;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 6981-18-6.mol

5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Chemical Properties

• Melting point: 231.0 to 235.0 °C
• Boiling point: 521.5±60.0 °C(Predicted)
• density: 1.223±0.06 g/cm3(Predicted)
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
• pka: 7.11±0.10(Predicted)
• form: Solid
• color: Off-White
• Water Solubility: Water: Insoluble
• λmax: 287nm(CHCl3)(lit.)
• Stability: Hygroscopic
• CAS DataBase Reference: 6981-18-6(CAS DataBase Reference)
• EPA Substance Registry System: Ormetoprim (6981-18-6)

Safety Information

• Safety Statements: 24/25
• HS Code: 29333990

5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Usage And Synthesis

Uses

It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial.This compound is a contaminant of emerging concern (CECs).

Definition

ChEBI: 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine is a dimethoxybenzene.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 14, p. 462, 1971 DOI: 10.1021/jm00287a029

in vivo

Ormetoprim (8.3 mg/kg; i.p.) exhibits absorption half-life (5.4 h), elimination half-life (7.5 h) and C_max (1.2±0.2 μg/mL)^[3].
Ormetoprim (8.3 mg/kg; p.o.) exhibits absorption half-life (3.9 h), elimination half-life (3.9 h), C_max (1.6±0.4 μg/mL) and oral availability (78.5%) relative to intraperitoneal administration^[3].

• Animal Model: Hybrid striped bass (565-805 g)^[3]
• Dosage: 50 mg/kg Sulfadimethoxine and Ormetoprim in a 5:1 ratio (Pharmacokinetic Analysis)
• Administration: I.p. and p.o. administration
• Result: I.p.: t_1/2(elim)=7.5 h; t_1/2(abs)=5.4 h; C_max=1.2 μg/mL. P.o.: t_1/2(elim)=3.9 h; t_1/2(abs)=3.9 h; C_max=1.6 μg/mL; F=78.5%.