5-(Aminomethyl)-2-chloropyridine CAS 97004-04-1
5-(Aminomethyl)-2-chloropyridine Basic information
| Product Name: | 5-(Aminomethyl)-2-chloropyridine |
| Synonyms: | 2-CHLORO-5-AMINOMETHYLPYRIDINE;5-AMINOMETHYL-2-CHLOROPYRIDINE;3-AMINOMETHYL-6-CHLORO PYRIDINE;(6-CHLOROPYRIDIN-3-YL)METHYLAMINE;(6-CHLOROPYRIDIN-3-YL)METHANAMINE;6-CHLORO-3-PYRIDINEMETHYLAMINE;6-chloro-3-pyridinemethanamine;1-(6-CHLOROPYRIDIN-3-YL)METHANAMINE |
| CAS: | 97004-04-1 |
| MF: | C6H7ClN2 |
| MW: | 142.59 |
| EINECS: | 619-497-6 |
| Product Categories: | Aminomethyl's;Pyridines;Pyridine;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks |
| Mol File: | 97004-04-1.mol |
5-(Aminomethyl)-2-chloropyridine Chemical Properties
| Melting point | 28-34 °C |
| Boiling point | 101-102°C 1mm |
| density | 1.244±0.06 g/cm3(Predicted) |
| Fp | >230 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 7.78±0.29(Predicted) |
| form | Oil to Low-Melting Solid |
| color | Off-White to Light Brown |
| Sensitive | Hygroscopic |
| BRN | 8308740 |
| Stability: | Hygroscopic |
| InChI | InChI=1S/C6H7ClN2/c7-6-2-1-5(3-8)4-9-6/h1-2,4H,3,8H2 |
| InChIKey | XPARFBOWIYMLMY-UHFFFAOYSA-N |
| SMILES | C1=NC(Cl)=CC=C1CN |
| CAS DataBase Reference | 97004-04-1(CAS DataBase Reference) |
Safety Information
| Hazard Codes | T,C |
| Risk Statements | 25-37/38-41-43-34 |
| Safety Statements | 26-36/37/39-45-20 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 2933399990 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
| Chemical Properties | White to Off-white crystal |
| Uses | 5-Aminomethyl-2-chloropyridine is a reagent that is used in the synthesis of macamides and analogs that have FAAH (fatty acid amide hydrolase) inhibitory activity. |
| Synthesis | 1080018-12-7 97004-04-1 General procedure for the synthesis of 5-aminomethyl-2-chloropyridine from the compound (CAS:1080018-12-7) (Example 5): preparation of (2-chloropyridin-5-yl)methylamine (4). To 0.77 g (1.66 mmol) of 1,3,5-tris[(2-chloropyridin-5-yl)methyl]-1,3,5-perhydrotriazine (II-4) were sequentially added 0.40 g of methanol and 1.83 g of concentrated hydrochloric acid, and the resultant mixture was stirred for 6 hr. at 75 to 80° C. The reaction was carried out with the aid of a liquid chromatograph. After completion of the reaction, the reaction mixture was diluted with chloroform and adjusted to basicity by addition of 28% aqueous sodium hydroxide. The chloroform layer was separated and concentrated to give 0.68 g (yield: 95%) of the target product (2-chloropyridin-5-yl)methylamine (III-1). |
| References | [1] Patent: EP2141149, 2010, A1. Location in patent: Page/Page column 17 [2] Patent: US2010/121054, 2010, A1. Location in patent: Page/Page column 9 |
5-(Aminomethyl)-2-chloropyridine Preparation Products And Raw materials
| Raw materials | Ethanol-->Sodium hydroxide-->Ammonium hydroxide-->Hydrogen-->Nickel-->Hexamethylenetetramine-->Formamide-->2-Chloropyridine-->RANEY NICKEL-->2-chloro-5-cyanopyridine |
| Preparation Products | Acetamiprid-->3-Pyridinemethanamine,6-methoxy-(9CI) |
