Introduction：Basic information about 5-Azaindole CAS 271-34-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
5-Azaindole Basic information
| Product Name: | 5-Azaindole |
| Synonyms: | 5-Azaindole ,98%;5-Azaindole,1H-pyrrolo[3,2-c]pyridine;5-Aza-1H-indole;5-Azaindole (1,5-Diazaindene 3,7-Dideazapurine);HARMYRINE;1H-PYRROLO[3,2-C]PYRIDINE;1,6-DIAZAINDENE;1,5-DIAZAINDENE |
| CAS: | 271-34-1 |
| MF: | C7H6N2 |
| MW: | 118.14 |
| EINECS: | 676-348-8 |
| Product Categories: | Indoles and derivatives;Indole;Heterocyclic Compounds;Indole Series;Azaindoles;Heterocycle-Indole series;Azaindole;Building Blocks |
| Mol File: | 271-34-1.mol |
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5-Azaindole Chemical Properties
| Melting point | 104.6-108.4°C |
| Boiling point | 132°C/0.2mmHg(lit.) |
| density | 1.242±0.06 g/cm3(Predicted) |
| RTECS | UY8725000 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder to crystal |
| pka | 15.20±0.30(Predicted) |
| color | White to Light yellow |
| Water Solubility | Hardly soluble in water. Soluble in methanol and chloroform. |
| λmax | 264nm(H2O)(lit.) |
| InChI | InChI=1S/C7H6N2/c1-4-9-7-2-3-8-5-6(1)7/h1-5,9H |
| InChIKey | SRSKXJVMVSSSHB-UHFFFAOYSA-N |
| SMILES | C1=NC=CC2NC=CC1=2 |
| CAS DataBase Reference | 271-34-1(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-41-37/38-22 |
| Safety Statements | 26-36/37/39-39 |
| Hazard Note | Irritant |
| HS Code | 29339980 |
5-Azaindole Usage And Synthesis
| Chemical Properties | White to yellow (crystals) |
| Uses | 5-Azaindole is a factor VIIa inhibitor. Also useful intermediate for pharmaceutical application. |
| Synthesis Reference(s) | Tetrahedron, 49, p. 2885, 1993 DOI: 10.1016/S0040-4020(01)80387-2 |
| References | [1] E. A. LAPAN L. Y. Reductive dealkoxylation of 5-azaindole derivatives[J]. Chemistry of Heterocyclic Compounds, 1972, 8 1: 781-782. DOI:10.1007/BF00487485.
[2] JENNIFER R. RIGGS. Novel 5-azaindole factor VIIa inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16 12: Pages 3197-3200. DOI:10.1016/j.bmcl.2006.03.049.
[3] SHIGENOBU OKUDA Micahel R. Notes- The Synthesis of 5-Azaindole[J]. The Journal of Organic Chemistry, 1959, 24 7: 1008-1011. DOI:10.1021/jo01089a616. |
5-Azaindole Preparation Products And Raw materials
| Raw materials | Sodium hydroxide-->Hydrochloric acid-->Ethyl acetate-->Sulfuric acid-->Tetrahydrofuran-->Dichloromethane-->Acetic acid-->N,N-Dimethylformamide-->Nitric acid-->n-Butyllithium-->Hexane-->Hydrogen peroxide-->Palladium-->Di-tert-butyl dicarbonate-->N,N-Dimethylformamide dimethyl acetal-->N-Methylaniline-->Isopropyl acetate-->Ammonium formate-->L(+)-Tartaric acid-->3-Picoline-->3-Methyl-4-nitropyridine N-Oxide-->NICKEL ALUMINIDE-->3-Methyl-4-aminopyridine |
