5-Chloro-2-nitroaniline CAS 1635-61-6
Introduction：Basic information about 5-Chloro-2-nitroaniline CAS 1635-61-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
5-Chloro-2-nitroaniline Basic informationDescription Preparation
| Product Name: | 5-Chloro-2-nitroaniline |
| Synonyms: | TIMTEC-BB SBB003828;2-AMINO-4-CHLORO-NITROBENZENE;5-CHLORO-2-NITROANILINE;5-CHLORO-2-NITROBENZENAMINE;5-chloro-2-nitro-benzenamin;Benzenamine, 5-chloro-2-nitro-;2-NITRO-5-CHLOROANILINE;2-Amino-4-chloro-1-nitrobenzene |
| CAS: | 1635-61-6 |
| MF: | C6H5ClN2O2 |
| MW: | 172.57 |
| EINECS: | 216-661-5 |
| Product Categories: | Pyrimidines;API intermediates |
| Mol File: | 1635-61-6.mol |
5-Chloro-2-nitroaniline Chemical Properties
| Melting point | 125-129 °C (dec.)(lit.) |
| Boiling point | 200°C (rough estimate) |
| density | 1.5610 (rough estimate) |
| refractive index | 1.5870 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Chloroform, Methanol |
| form | Liquid |
| pka | -1.46±0.25(Predicted) |
| color | Clear colorless to light yellow |
| BRN | 2210201 |
| InChI | InChI=1S/C6H5ClN2O2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H,8H2 |
| InChIKey | ZCWXYZBQDNFULS-UHFFFAOYSA-N |
| SMILES | C1(N)=CC(Cl)=CC=C1[N+]([O-])=O |
| CAS DataBase Reference | 1635-61-6(CAS DataBase Reference) |
Safety Information
| Hazard Codes | T+,N,T |
| Risk Statements | 26/27/28-33-51/53 |
| Safety Statements | 28-36/37-45-61-28A |
| RIDADR | UN 2237 6.1/PG 3 |
| WGK Germany | 3 |
| F | 9-23 |
| Hazard Note | Irritant |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29214210 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 1 Dermal Acute Tox. 2 Inhalation Acute Tox. 2 Oral Aquatic Chronic 2 STOT RE 2 |
| Description | 2-Nitro-5-chloroaniline is an important pharmaceutical and veterinary drug intermediate. It has been applied in the upgraded product of veterinary drug albendazole-fenbendazole, and has a broad market prospect. |
| Preparation | Add 2.46mol of 2,4-dichloronitrobenzene, 7.72mol of toluene to a 3L autoclave, seal the autoclave, replace the air with nitrogen, then pass in 14.1mol of liquid ammonia, increase the temperature to 160℃, continue the reaction for 8h, and then lower the temperature to 40℃, drain the excess ammonia gas, open the kettle, add the obtained solid-liquid mixture to 800mL of water, continue to cool to 10℃, filter, add the resulting filter cake to the water, continue beating and filtering, the obtained solid is crystallized with methanol to obtain 388g , yield 91.2%, the purity of the liquid phase external standard is 99.5%. |
| Chemical Properties | yellow to orange powder |
| Uses | 5-Chloro-2-nitroaniline is a useful synthetic intermediate. It can be used as a reagent to synthesize benzamide derivatives as histone deacetylase inhibitors. It is an intermediate used to synthesize 1-Nitro Febantel a Febantel impurity. |
| Uses | 5-Chloro-2-nitroaniline was used in the synthesis of 5-(4-substituted piperazin-1-yl)-2-nitroanilines and 5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates. |
| Application | 5-Chloro-2-nitroaniline was used in the synthesis of 5-(4-substituted piperazin-1-yl)-2-nitroanilines and 5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates. The coupling of divinylbenzene cross-linked polystyrene with 5-chloro-2-nitroaniline followed by oxidative decyanation afforded benzophenone. |
| General Description | The coupling of divinylbenzene cross-linked polystyrene with 5-chloro-2-nitroaniline followed by oxidative decyanation afforded benzophenone. |
5-Chloro-2-nitroaniline Preparation Products And Raw materials
| Preparation Products | Fenbendazole-->6-CHLOROQUINOXALINE-->2,3,6-TRICHLOROQUINOXALINE-->6-CHLORO-2,3-DIOXO-1,2,3,4-TETRAHYDROQUINOXALINE-->4-FLUORO-2-NITROBENZONITRILE-->4-Chloro-o-phenylenediamine-->2-Amino-5-chlorobenzenesulfonamide-->Hoechst 33342-->3,4-DiaMinodiphenyl ether-->5-Chloro-2-nitrophenol-->5-(4-BENZYLPIPERAZINO)-2-NITROANILINE-->2-NITRO-5-PYRROLIDIN-1-YL-PHENYLAMINE-->Benzenamine, 5-[(4-methylphenyl)thio]-2-nitro--->Carbamic acid, N-(5-chloro-2-nitrophenyl)-N-methyl-, 1,1-dimethylethyl ester-->(5-CHLORO-2-NITROPHENYL)HYDRAZINE-->2-[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]ethan-1-ol |
