Introduction：Basic information about 5-Methylisatin CAS 608-05-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
5-Methylisatin Basic information
| Product Name: | 5-Methylisatin |
| Synonyms: | AURORA 1898;BUTTPARK 34\07-89;IFLAB-BB F0266-0774;5-methylindole-2,3(1H)-dione;5-METHYL-1H-INDOLE-2,3-DIONE;5-METHYLISATIN;5-METHYLINDOLE-2,3-DIONE;AKOS BBS-00000995 |
| CAS: | 608-05-9 |
| MF: | C9H7NO2 |
| MW: | 161.16 |
| EINECS: | 210-152-1 |
| Product Categories: | Building Blocks;C7 to C9;Chemical Synthesis;Heterocyclic Building Blocks;Indane/Indanone and Derivatives;Indoles;Simple Indoles |
| Mol File: | 608-05-9.mol |
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5-Methylisatin Chemical Properties
| Melting point | 180 °C (dec.) (lit.) |
| density | 1.301±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | methanol: soluble25mg/mL, clear to slightly hazy, orange to red |
| pka | 10.42±0.20(Predicted) |
| form | crystalline |
| color | orange |
| BRN | 123738 |
| InChI | InChI=1S/C9H7NO2/c1-5-2-3-7-6(4-5)8(11)9(12)10-7/h2-4H,1H3,(H,10,11,12) |
| InChIKey | VAJCSPZKMVQIAP-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(C)C=C2)C(=O)C1=O |
| CAS DataBase Reference | 608-05-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 5-Methyl-2,3-indolinedione(608-05-9) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | NL7939300 |
| HazardClass | IRRITANT |
| HS Code | 29337900 |
| Storage Class | 11 - Combustible Solids |
5-Methylisatin Usage And Synthesis
| Chemical Properties | Red to brown powder or crystals |
| Uses | Reactant for preparation of:
- Antimycobacterial agents
- Promoters of central nervous system (CNS) depression in mice
- Inhibitors of TAK1 kinase
- Anti-human immunodeficiency virus (HIV) agent
- Potent herpes simplex virus (HSV) inhibitors
- Antimicrobial agents
- IKKβ inhibitors
- Potential drug to combat human immunodeficiency virus-tuberculosis (HIV-TB) coinfection
- Cyclooxygenase 1/2 (COX-1/2) and 5-lipoxygenase (5-LOX) inhibitors
- Antibacterial and anticancer agents
|
| Uses | Reactant for preparation of:• ;Antimycobacterial agents1• ;Promoters of central nervous system (CNS) depression in mice2• ;Inhibitors of TAK1 kinase3• ;Anti-human immunodeficiency virus (HIV) agent4• ;Potent herpes simplex virus (HSV) inhibitors5• ;Antimicrobial agents6• ;IKKβ inhibitors7• ;Potential drug to combat human immunodeficiency virus-tuberculosis (HIV-TB) coinfection8• ;Cyclooxygenase 1/2 (COX-1/2) and 5-lipoxygenase (5-LOX) inhibitors9• ;Antibacterial and anticancer agents |
| General Description | 5-Methylisatin is an inhibitor of atrial natriuretic peptide (ANP) receptor coupled with guanylyl cyclase (GC). |
5-Methylisatin Preparation Products And Raw materials
| Preparation Products | 2,4(1H,3H)-Quinazolinedione, 6-methyl--->2-AMINO-5-METHYLBENZAMIDE-->2-Amino-5-Methyl-Benzonitrile-->2-(2-FURYL)-6-METHYLQUINOLINE-4-CARBOXYLIC ACID-->6-METHYL-2-THIEN-2-YLQUINOLINE-4-CARBOXYLIC ACID-->2,3-Benzofurandione, 5-methyl--->Benzenamine, 2-(1H-benzimidazol-2-yl)-4-methyl--->CHEMBRDG-BB 9071062-->6-METHYL-2-(4-METHYLPHENYL)QUINOLINE-4-CARBOXYLICACID-->3,3-Difluoro-5-methyl-1,3-dihydro-indol-2-one |
