Introduction：Basic information about 5-Methyluridine CAS 1463-10-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
5-Methyluridine Basic information
| Product Name: | 5-Methyluridine |
| Synonyms: | 5-methyl-uridin;5-methyuridine;5-Methyluridine (Patent );THYMINERIBOSIDE;URIDINE, 5-METHYL-;5-METHYLURIDINE(5-Methyl-1-ˉ-ribofuranosyl uracil;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione;5-methyluridine/ribothymidine |
| CAS: | 1463-10-1 |
| MF: | C10H14N2O6 |
| MW: | 258.23 |
| EINECS: | 215-973-9 |
| Product Categories: | Carbohydrates & Derivatives;Heterocycles;Biochemistry;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Bases & Related Reagents;Nucleotides;Pyridines, Pyrimidines, Purines and Pteredines;Miscellaneous Biochemicals;Nucleotides and Nucleosides;bc0001 |
| Mol File: | 1463-10-1.mol |
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5-Methyluridine Chemical Properties
| Melting point | 183-184 °C(lit.) |
| density | 1.576±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Methanol (Slightly, Heated, Sonicated), Water (Sparingly, Sonicated) |
| pka | 9.55±0.10(Predicted) |
| form | powder |
| color | white |
| PH | 9.7 |
| Optical Rotation | -8.9°(C=1 g/100ml H2O) |
| λmax | 267 (pH 1)；268 (pH 13) |
| InChI | InChI=1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,9-/m1/s1 |
| InChIKey | DWRXFEITVBNRMK-JXOAFFINSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](O)[C@@H]1O |
| CAS DataBase Reference | 1463-10-1(CAS DataBase Reference) |
Safety Information
| Hazard Codes | T+ |
| Risk Statements | 26/27/28 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
5-Methyluridine Usage And Synthesis
| Description | 5-Methyluridine is a pyrimidine nucleoside and methylated form of uridine. It is the ribonucleoside counterpart to the deoxyribonucleoside thymidine, which lacks a hydroxyl group at the 2' position. 5-Methyluridine contains a thymine base joined to a ribose pentose sugar. It is an endogenous methylated nucleoside found in human fluids. In cells, 5-methyluridine is present in tRNA, formed during its post-transcriptional modification by the methylation of uridine. |
| Chemical Properties | White Powder |
| Uses | A primary degradation product of tRNA, an urinary nucleoside as biological marker for patients with colorectal cancer.
It enhances the antitumor activity of 5-fluorouracil in a mouse Erlich solid carcinoma model and a P388 murine leukemia model. It has been used to characterize the activity of a variety of enzymes, including uridine nucleosidase. |
| Definition | ChEBI: Ribothymidine is a methyluridine having a single methyl substituent at the 5-position on the uracil ring. It has a role as a human metabolite, an Escherichia coli metabolite and an antigen. |
5-Methyluridine Preparation Products And Raw materials
| Raw materials | Uridine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-5-methyl- (9CI)-->Uridine, 5-methyl-5'-O-(triphenylmethyl)--->Uridine, 5-methyl-, 2',3',5'-triacetate-->Uridine, 5-methyl-, 2',3',5'-tribenzoate-->2'-O-[2-[(diMethylaMino)oxy]ethyl]-5-Methyl-uridine-->beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate-->1,2,3,5-TETRA-O-ACETYL-BETA-L-RIBOFURANOSE-->N3-Methyl-5-methyluridine-->BIS(O-TRIMETHYLSILYL)THYMINE-->Triethylamine trihydrofluoride-->Thymine-->Guanosine |
| Preparation Products | THYMINE-BETA-D-ARABINOFURANOSIDE-->Ethyl benzoate-->Stavudine |
