6-Iodoquinazolin-4-one CAS 16064-08-7

Introduction：Basic information about 6-Iodoquinazolin-4-one CAS 16064-08-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

6-Iodoquinazolin-4-one Basic information

• Product Name: 6-Iodoquinazolin-4-one
• Synonyms: 6-Iodo-4(1H)-quinazolinone;6-Iodo-4-quinazolinol;6-Iodoquin;6-Iodo-4-quinazolinol6-Iodo-4-quinazolinone;6-iodoquinazolin-4(3H)-one;4-Hydroxy-6-iodoquinazoline;TIMTEC-BB SBB005376;6-Iodoquinazolin-4-one,95+
• CAS: 16064-08-7
• MF: C8H5IN2O
• MW: 272.04
• EINECS: 605-218-5
• Product Categories: pharmacetical;Lapatinib
• Mol File: 16064-08-7.mol

6-Iodoquinazolin-4-one Chemical Properties

• Melting point: 271°C(lit.)
• Boiling point: 401.0±47.0 °C(Predicted)
• density: 2.11±0.1 g/cm3(Predicted)
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
• form: Solid
• pka: 1.00±0.20(Predicted)
• color: White to Off-White
• InChI: InChI=1S/C8H5IN2O/c9-5-1-2-7-6(3-5)8(12)11-4-10-7/h1-4H,(H,10,11,12)
• InChIKey: PUGXMZKDRVGIHC-UHFFFAOYSA-N
• SMILES: N1C2=C(C=C(I)C=C2)C(=O)NC=1
• CAS DataBase Reference: 16064-08-7(CAS DataBase Reference)

Safety Information

• Risk Statements: 36
• Safety Statements: 26
• HS Code: 2914390090

6-Iodoquinazolin-4-one Usage And Synthesis

Chemical Properties

White Solid

Uses

6-Iodoquinazolin-4-one is an intermediate in the synthesis of Lapatinib (L175800).

Synthesis

5326-47-6

149-73-5

16064-08-7

Using 2-amino-5-iodobenzoic acid and trimethyl orthoformate as starting materials, the synthesis procedure of Examples I-2 was followed, but the reaction solvent was replaced from methanol to acetonitrile. Upon completion of the reaction, 6-iodoquinazolin-4-one was obtained by post-processing in a yield of 0.98 g and 94% yield.

References

[1] Patent: EP1477481, 2004, A1. Location in patent: Page 17
[2] Patent: EP1477481, 2004, A1. Location in patent: Page 16-17
[3] Patent: EP1477481, 2004, A1. Location in patent: Page 17
[4] Patent: EP1477481, 2004, A1. Location in patent: Page 17
[5] Patent: EP1477481, 2004, A1. Location in patent: Page 17

6-Iodoquinazolin-4-one Preparation Products And Raw materials

• Raw materials: Acetic acid-->Potassium hydroxide-->Sodium bisulfite-->Iodine-->Formamide-->Anthranilic acid-->2-AMINO-5-IODOBENZAMIDE-->Formamidine acetate-->formamide-->2-Amino-5-iodobenzoic acid
• Preparation Products: 5-(4-Hydroxy-6-quinazolinyl)furan-2-carbaldehyde