7-BROMO-4-CHLOROQUINAZOLINE CAS 573675-55-5
Introduction：Basic information about 7-BROMO-4-CHLOROQUINAZOLINE CAS 573675-55-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
7-BROMO-4-CHLOROQUINAZOLINE Basic information
| Product Name: | 7-BROMO-4-CHLOROQUINAZOLINE |
| Synonyms: | 7-Bromo-4-chloro-quizoline;7-BroMo-4-chloroquinazoli...;7-BROMO-4-CHLOROQUINAZOLINE;Quinazoline, 7-bromo-4-chloro- |
| CAS: | 573675-55-5 |
| MF: | C8H4BrClN2 |
| MW: | 243.49 |
| EINECS: | |
| Product Categories: | Halides;CHIRAL CHEMICALS;Fused Ring Systems |
| Mol File: | 573675-55-5.mol |
7-BROMO-4-CHLOROQUINAZOLINE Chemical Properties
| Boiling point | 339.7±22.0 °C(Predicted) |
| density | 1.762±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 0.09±0.30(Predicted) |
| Appearance | Off-white to light yellow Solid |
Safety Information
| Hazard Codes | T |
| Risk Statements | 41-25 |
| Safety Statements | 26-39-45 |
| RIDADR | UN2811 |
| HS Code | 2933599590 |
| Synthesis | 194851-16-6 573675-55-5 General procedure for the synthesis of 7-bromo-4-chloroquinazoline from 7-bromo-3,4-dihydroquinazolin-4-one: 20.4 mL (0.12 mol) of N-ethyl diisopropylamine was added slowly and dropwise to 55.0 g (0.24 mol) of 7-bromo-3H-quinazolin-4-one suspended in 300 mL of phosphorus trichloride. The reaction mixture was stirred at 115 °C for 3 hours and subsequently cooled to room temperature. After conventional post-processing, 48.0 g of the target product 7-bromo-4-chloroquinazoline was obtained as a solid as confirmed by HPLC/MS analysis ([M+H]+ = 244). |
| References | [1] Patent: US2013/12489, 2013, A1. Location in patent: Paragraph 0183 [2] Patent: WO2010/146173, 2010, A1. Location in patent: Page/Page column 16-17 [3] Patent: WO2005/42498, 2005, A2. Location in patent: Page/Page column 43 [4] Chemical Biology and Drug Design, 2018, vol. 92, # 5, p. 1859 - 1866 |
7-BROMO-4-CHLOROQUINAZOLINE Preparation Products And Raw materials
| Raw materials | 7-BROMO-1H-QUINAZOLIN-4-ONE |
