ARSENAZO III CAS 1668-00-4
Introduction：Basic information about ARSENAZO III CAS 1668-00-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
ARSENAZO III Basic information
| Product Name: | ARSENAZO III |
| Synonyms: | 2,7-bis(2-Arsonophenylazo)-1,8-dihydroxynaphthalene-3,6-disulfonicacid,sodiumsalt;2,7-Naphthalenedisulfonicacid,3,6-bis[(2-arsonophenyl)azo]-4,5-dihydroxy-;7-Naphthalenedisulfonicacid,3,6-bis[(2-arsonophenyl)azo]-4,5-dihydroxy-2;ARSENAZO III SODIUM SALT;Arsenazo Ⅲ;2,2'-(1,8-DIHYDROXY-3,6-DISULFO-2,7-NAPHTHALENE-BIS(AZO))DIBENZENEARSONIC ACID SODIUM SALT;2,7-(bis(2-arsonophenylazo))-1,8-dihydroxynaphthalene-3,6-disulphonic acid;ARSENAZO III, REAG. |
| CAS: | 1668-00-4 |
| MF: | C22H18As2N4O14S2 |
| MW: | 776.37 |
| EINECS: | 216-788-6 |
| Product Categories: | Analytical Chemistry;As (Arsenic) Compounds;Azo Compounds;Chelating Reagents;Classes of Metal Compounds;Naphthylazo Compounds;Semimetal Compounds;Pharmaceutical Intermediates |
| Mol File: | 1668-00-4.mol |
ARSENAZO III Chemical Properties
| Melting point | >320 °C(lit.) |
| bulk density | 850kg/m3 |
| storage temp. | Store below +30°C. |
| solubility | ammonium hydroxide: soluble1mg/mL |
| pka | -1.25±0.40(Predicted) |
| form | Powder |
| color | Brown |
| PH | 2.3 (10g/l, H2O, 20℃) |
| λmax | 569-576 nm (buffer pH 10.0) |
| BRN | 5717957 |
| Major Application | diagnostic assay manufacturing hematology histology |
| InChIKey | UQHVTNUJRKELCE-UHFFFAOYSA-N |
| SMILES | C1=C2C(C(O)=C(N=NC3=CC=CC=C3[As](O)(O)=O)C(S(O)(=O)=O)=C2)=C(O)C(N=NC2=CC=CC=C2[As](O)(O)=O)=C1S(O)(=O)=O |
Safety Information
| Hazard Codes | T,N |
| Risk Statements | 23/25-50/53 |
| Safety Statements | 20/21-28-45-60-61 |
| RIDADR | UN 3465 6.1/PG 2 |
| WGK Germany | 3 |
| HS Code | 2931 90 00 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Inhalation Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 1 |
| Chemical Properties | Dark brown solid |
| Uses | Spectrophotometric reagent for U, Th, Zr and other metals.Indicator for the precipitation titration of SO4 with Ba. |
| Uses | Arsenazo III is usually used in the determination of calcium in serum,has been used to evaluate calcium transport in permeabilized cells,has also been used for the spectrophotometric determination of uranium and thorium. |
| Uses | Arsenazo III reacts with more than 30 metal ions to give coloured complexes.So far it has been utilized for the determination and detection of about 25 metalions (including 16 rare earth metals). The majority of the analytical proceduresare spectrophotometric. The absorption spectra of the metal complexes of Arsenazo III possess twomaxima at about 610 and 665 nm. Since the absorption of the reagent is very lowat 665 nm, but is considerable at 610 nm, the extinction of the complexes at 665nm is utilized for analytical purposes. At this wavelength the molar extinctioncoefficients of the complexes lie in the range 5 x 104—1.3 x 105. This explains theextremely high analytical sensitivity of the reagent. (Under optimum conditionsthe sensitivity may reach 0.01 γ/ml.). The main advantage of Arsenazo III over Arsenazo I lies in the considerablyhigher stabilities of the complexes of the former. This makes possible the analyticalutilization of the reagent in strong mineral acidic media. It gives complexes withtri- and tetravalent metal ions in acidic media where hydrolysis and the consequentformation of polynuclear species do not interfere with the analyticallyutilized reaction. Those metals whose complexes form only in solutions of higherpH do not interfere with the analytical determination of the metal ions givingcomplexes in strongly acidic media (thorium, zirconium, uranium, plutonium,neptunium, etc.). This is the reason of the relatively high analytical selectivity ofArsenazo III. Trace amounts of zirconium can be enriched before determination by coprecipitationwith titanium hydroxide. The titanium hydroxide precipitate containingthe zirconium content of the sample is dissolved in 6 M hydrochloric acidsolution and the zirconium determined photometrically with Arsenazo III.Thousand-fold amounts of titanium do not interfere with the determination ofzirconium. The absorption maximum of the zirconium complex of Arsenazo IIIis at 665 nm. |
| Biological Activity | Arsenazo III is a metallochromic dye. Arsenazo III is used in the determination of calcium in biological samples. It is used to evaluate calcium transport in permeabilized cells. It is also used for the detection of rare earth metals (polyvalent metal ions). Arsenazo III is used for the spectrophotometric determination of uranium and thorium. |
ARSENAZO III Preparation Products And Raw materials
| Raw materials | Hydrochloric acid-->Sodium nitrite-->Urea-->1,8-Dihydroxynaphthylene-3,6-disulfonic acid-->2-Aminobenzenearsonic acid |
