Calcium phosphate dibasic CAS 7757-93-9

Introduction：Basic information about Calcium phosphate dibasic CAS 7757-93-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Calcium phosphate dibasic Basic information

• Product Name: Calcium phosphate dibasic
• Synonyms: calciumdibasicphosphate;calciumperphosphate,ammonified,granular;calciumphosphate(1:1);CALCIUM ORTHOPHOSPHATE;CALCIUM MONOHYDROGEN PHOSPHATE;CALCIUM MONOHYDROGEN PHOSPHATE, DIBASIC;CALCIUM PHOSPHATE, DIBASIC;CALCIUM HYDROGEN ORTHOPHOSPHATE
• CAS: 7757-93-9
• MF: CaHO4P
• MW: 136.06
• EINECS: 231-826-1
• Product Categories: Inorganics;Inorganic Chemicals;metal phosphate compound;Food Additives;7757-93-9
• Mol File: 7757-93-9.mol

Calcium phosphate dibasic Chemical Properties

• Melting point: 370°C(decomposition)
• density: 2.306（16℃）
• RTECS: TB8528000
• storage temp.: 2-8°C
• solubility: Practically insoluble in water and in ethanol (96 per cent). It dissolves in dilute hydrochloric acid and in dilute nitric acid.
• form: gel (aged)
• color: White
• PH: 7 (10g/l, H2O, 20°C) suspension
• Water Solubility: Sparingly soluble in water, practically insoluble in cold water.
• Merck: 13,1697
• Solubility Product Constant (Ksp): pKsp: 7
• Stability: Stable. Incompatible with strong oxidizing agents.
• Major Application: pharmaceutical (small molecule)
• Cosmetics Ingredients Functions: OPACIFYING ORAL CARE BULKING ABRASIVE
• Cosmetic Ingredient Review (CIR): Calcium phosphate dibasic (7757-93-9)
• InChI: 1S/Ca.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+2;/p-2
• InChIKey: FUFJGUQYACFECW-UHFFFAOYSA-L
• SMILES: [Ca++].OP([O-])([O-])=O
• LogP: -2.148 (est)
• CAS DataBase Reference: 7757-93-9(CAS DataBase Reference)
• EPA Substance Registry System: Calcium hydrogen phosphate (7757-93-9)

Safety Information

• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-24/25-22
• WGK Germany: 3
• TSCA: TSCA listed
• HS Code: 2835 25 00
• Storage Class: 11 - Combustible Solids
• Hazardous Substances Data: 7757-93-9(Hazardous Substances Data)
• Toxicity: LD50 orally in Rabbit: 10000 mg/kg LD50 dermal Rabbit > 7940 mg/kg

Calcium phosphate dibasic Usage And Synthesis

Chemical Properties

Dibasic Calcium Phosphate is anhydrous or contains two molecules of water of hydration. It occurs as a white, odorless, tasteless powder that is stable in air. It is practically insoluble in water, but is readily soluble in dilute hydrochloric and nitric acids. It is insoluble in alcohol.

Dibasic calcium phosphate is produced by the reaction of phosphoric acid, calcium chloride, and sodium hydroxide. Calcium carbonate can be used in place of the calcium chloride and sodium hydroxide.
Dibasic calcium phosphate anhydrous is generally regarded as relatively nontoxic and nonirritant material. It is widely used in oral pharmaceutical products and food products.
Functional Use in Foods: Leavening agent; dough conditioner; nutrient; dietary supplement; yeast food.

Uses

Dibasic calcium phosphate is found in nature as the mineral monetite. It is used as a food supplement and source of calcium, both in human food and animal feed. It is used in dough conditioner; in several dental products and in medicine. Other applications are in fertilizers, plastics and in the manufacture of glass.

Preparation

Dibasic calcium hydrogen phosphate may be prepared by several methods.
It is precipitated by mixing solutions of calcium chloride and disodium hydrogen phospate:CaCl2 + Na2HPO4 → CaHPO4 + 2NaCl
It also is prepared by treating phosphoric acid with lime water (suspension of calcium hydroxide in water). Also, it is obtained as a by-product in the preparation of hydroxypatite. The preparation involves the reaction of phosphoric acid with calcium phosphate.
H3PO4 + Ca3(PO4)2 → 3CaHPO4

Chemical Properties

Anhydrous dibasic calcium phosphate is a white, odorless, tastelesspowder or crystalline solid. It occurs as triclinic crystals.

Physical properties

White triclinic crystal; density 2.92 g/cm³ (anhydrous) and 2.31 g/cm³ (dihy drate); hardness 3.5 Mohs; decomposes on heating; inosluble in water and alcohol; KSP 2.7x10^-7; soluble in dilute mineral acid.

Uses

It is used as a feed additive for livestock and poultry. It can promote feed digestion, put on animal?s weight, raise laying rate or producing milk rate, cure diseases such as rickets, osteomalacia and anemia.

Uses

Replenisher(calcium); pharmaceutic aid (tablet base).

Production Methods

Calcium phosphates are usually prepared by reacting very purephosphoric acid with calcium hydroxide, Ca(OH)₂ obtained fromlimestone, in stoichiometric ratio in aqueous suspension followedby drying at a temperature that will allow the correct hydrationstate to be achieved. After drying, the coarse-grade material isobtained by means of a classification unit; the fine particle-sizematerial is obtained by milling. Dibasic calcium phosphate,anhydrous, may also be prepared by spray-drying.

Definition

ChEBI: Calcium hydrogenphosphate is a calcium phosphate.

Brand name

CalStar (FMC); D.C.P. (Parke-Davis).

Flammability and Explosibility

Non flammable

Agricultural Uses

Dicalcium phosphate (CaHPO₄) is made from calcium carbonate and phosphoric acid. It contains 34% citrate- soluble phosphorus pentoxide (P₂O₅). It is not commonly used as a fertilizer, but is used as a supplement to animal feed.

Pharmaceutical Applications

Anhydrous dibasic calcium phosphate is used both as an excipientand as a source of calcium in nutritional supplements. It is usedparticularly in the nutritional/health food sectors. It is also used inpharmaceutical products because of its compaction properties, andthe good flow properties of the coarse-grade material. Thepredominant deformation mechanism of anhydrous dibasic calciumphosphate coarse-grade is brittle fracture and this reduces thestrain-rate sensitivity of the material, thus allowing easier transitionfrom the laboratory to production scale. However, unlike thedihydrate, anhydrous dibasic calcium phosphate when compactedat higher pressures can exhibit lamination and capping. Thisphenomenon can be observed when the material represents asubstantial proportion of the formulation, and is exacerbated by theuse of deep concave tooling. This phenomenon also appears to beindependent of rate of compaction.
Anhydrous dibasic calcium phosphate is abrasive and a lubricantis required for tableting, for example 1% w/w magnesium stearateor 1% w/w sodium stearyl fumarate.
Two particle-size grades of anhydrous dibasic calcium phosphateare used in the pharmaceutical industry. Milled material is typicallyused in wet-granulated or roller-compacted formulations. The‘unmilled’ or coarse-grade material is typically used in directcompressionformulations.
Anhydrous dibasic calcium phosphate is nonhygroscopic andstable at room temperature. It does not hydrate to form thedihydrate.
Anhydrous dibasic calcium phosphate is used in toothpaste anddentifrice formulations for its abrasive properties.

Biological Activity

Calcium phosphate dibasic is an anhydrate used to dilute tablets and capsules. It is widely used as an excipient for its compressibility, amenability, and brittle fracture propensity.

Safety Profile

Skin and eye irritant. A nuisance dust.

Safety

Dibasic calcium phosphate anhydrous is widely used in oralpharmaceutical products, food products, and toothpastes, and isgenerally regarded as a relatively nontoxic and nonirritant material.

storage

Dibasic calcium phosphate anhydrous is a nonhygroscopic,relatively stable material. Under conditions of high humidity itdoes not hydrate to form the dihydrate.
The bulk material should be stored in a well-closed container in adry place.

Purification Methods

Crystallise it from a near-saturated solution in 50% aqueous reagent grade phosphoric acid at 100o by filtering through fritted glass and cooling to room temperature. The crystals are filtered off, and this process is repeated three times using fresh acid. For the final crystallisation the solution is cooled slowly with constant stirring to give thin plate crystals that are filtered off on a fritted glass funnel, washed free of acid with anhydrous acetone and dry in a vacuum desiccator [Egan et al.J Am Chem Soc 78 1811 1956].

Incompatibilities

Dibasic calcium phosphate should not be used to formulatetetracyline antibiotics.
The surface of milled anhydrous dibasic calcium phosphate isalkaline and consequently it should not be used with drugs thatare sensitive to alkaline pH. However, reports suggest there aredifferences in the surface alkalinity/acidity between the milled andunmilled grades of anhydrous dibasic calcium phosphate; theunmilled form has an acidic surface environment. This differencehas important implications for drug stability, particularly whenreformulating from, e.g. roller compaction to direct compression,when the particle size of the anhydrous dibasic calcium phosphatemight be expected to change.
Dibasic calcium phosphate dihydrate has been reported to beincompatible with a number of drugs and excipients, and many ofthese incompatibilities are expected to occur with dibasic calciumphosphate, anhydrous; see Calcium phosphate, dibasic dihydrate.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in theFDA Inactive Ingredients Database (oral capsules and tablets).Included in nonparenteral medicines licensed in Europe. Included inthe Canadian List of Acceptable Non-medicinal Ingredients.

Calcium phosphate dibasic Preparation Products And Raw materials

• Raw materials: Sulfuric acid-->Sodium chloride-->Urea-->Calcium oxide-->CALCIUM CARBONATE-->Potassium sulfate-->Calcium phosphate dibasic dihydrate-->Silicon dioxide-->Calcium phosphate monobasic-->phosphoric acid by wet process-->Phosphate rock powder-->Calcium phosphate monobasic-->Calcium chloride solution 36-40%, (1box=27kgs)-->calcium magnesium phosphate(CMP)-->PHOS ROCK FERTILIZER IN BULK-->Methyl Red-->CALCIUM SULFATE HEMIHYDRATE-->Acid Blue 93