CARBOXYMETHYLCELLULOSE CALCIUM CAS 9050-04-8
Introduction：Basic information about CARBOXYMETHYLCELLULOSE CALCIUM CAS 9050-04-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
CARBOXYMETHYLCELLULOSE CALCIUM Basic information
| Product Name: | CARBOXYMETHYLCELLULOSE CALCIUM |
| Synonyms: | Cellulose,ethers,carboxymethyl ether,calcium salt;N4-(2-Chloro-7-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine;hylon600;CMCCalcium;CALCIUMCARBOXYLMETHYLCELLULOSE;Calciam carboxymethylceUulose;Carboxymethylcellulose calcium (nf);Carmellose calcium (jp15) |
| CAS: | 9050-04-8 |
| MF: | C23H30ClN3O |
| MW: | 399.9568 |
| EINECS: | 618-597-7 |
| Product Categories: | |
| Mol File: | 9050-04-8.mol |
CARBOXYMETHYLCELLULOSE CALCIUM Chemical Properties
| solubility | Practically insoluble in acetone, chloroform, ethanol(95%), toluene, and ether. Insoluble in water, but swells to forma suspension. |
| Major Application | pharmaceutical (small molecule) |
| Cosmetics Ingredients Functions | FILM FORMING VISCOSITY CONTROLLING EMULSION STABILISING |
| InChI | InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-14-17(24)9-11-21(19)26-22-12-10-18(28-4)15-20(22)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) |
| InChIKey | SVUDQUZYHLUPQN-UHFFFAOYSA-N |
| SMILES | Clc1cc2c(nc3c(c2NC(CCCN(CC)CC)C)cc(cc3)OC)cc1 |
| EPA Substance Registry System | Cellulose, carboxymethyl ether, calcium salt (9050-04-8) |
Safety Information
| WGK Germany | WGK 3 |
| TSCA | TSCA listed |
| HS Code | 3912310000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Resp. Sens. 1 Skin Sens. 1 |
| Chemical Properties | DS 0.5-0.7 |
| Chemical Properties | Carboxymethylcellulose calcium occurs as a white to yellowishwhite,hygroscopic, odorless powder. |
| Uses | Pharmaceutic aid (tabletdisintegrant). |
| Production Methods | Cellulose, obtained from wood pulp or cotton fibers, is carboxymethylated,followed by conversion to the calcium salt. It is thengraded on the basis of its degree of carboxymethylation andpulverized. |
| Pharmaceutical Applications | The main use of carboxymethylcellulose calcium is in tabletformulations, where it is used as a binder, diluent,and disintegrant. Although carboxymethylcellulose calcium isinsoluble in water, it is an effective tablet disintegrant as it swells toseveral times its original bulk on contact with water. Concentrationsup to 15% w/w may be used in tablet formulations; above thisconcentration, tablet hardness is reduced. Carboxymethylcellulose calcium is also used in other applicationssimilarly to carboxymethylcellulose sodium; for example, as asuspending or viscosity-increasing agent in oral and topicalpharmaceutical formulations. Carboxymethylcellulose calcium isalso used in modern wound dressings for its water absorption,retention and hemostatic properties. |
| Safety | Carboxymethylcellulose calcium is used in oral and topicalpharmaceutical formulations, similarly to carboxymethylcellulosesodium, and is generally regarded as a nontoxic and nonirritantmaterial. However, as with other cellulose derivatives, oralconsumption of large amounts of carboxymethylcellulose calciummay have a laxative effect. |
| storage | Carboxymethylcellulose calcium is a stable, though hygroscopicmaterial. It should be stored in a well-closed container in a cool, dryplace. |
| Regulatory Status | Included in the FDA Inactive Ingredients Database (oral, capsulesand tablets). Included in nonparenteral medicines licensed in theUK. Included in the Canadian List of Acceptable Non-medicinalIngredients. |
CARBOXYMETHYLCELLULOSE CALCIUM Preparation Products And Raw materials
| Raw materials | Calcium hydroxide-->Sodium carboxymethyl cellulose |
