Ciprofloxacin hydrochloride hydrate CAS 86393-32-0

Introduction：Basic information about Ciprofloxacin hydrochloride hydrate CAS 86393-32-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Ciprofloxacin hydrochloride hydrate Basic information

• Product Name: Ciprofloxacin hydrochloride hydrate
• Synonyms: 3-QUINOLINECARBOXYLIC ACID HYDROCHLORIDE;CIPROFLOXACIN HCL/ CIPROFLOXACIN MONOHYDROCHLORIDE;CIPROFLOXACIN HCL USP;CIPROFLOXACINHYDROCHLORIDE,USP;oride Monohydrate;1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrate hydrochloride;1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride hydrate;Ciprofloxacin hydrochloride hydrate
• CAS: 86393-32-0
• MF: C17H21ClFN3O4
• MW: 385.82
• EINECS: 617-845-1
• Product Categories: Peptide Synthesis/Antibiotics;Quinolones (Antibiotics for Research and Experimental Use);Antibiotics for Research and Experimental Use;Biochemistry;Antibiotic Explorer;Active Pharmaceutical Ingredients;Pharmaceutical raw materials;API
• Mol File: 86393-32-0.mol

Ciprofloxacin hydrochloride hydrate Chemical Properties

• Melting point: 318-320 °C
• RTECS: VB1993800
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: Soluble in water, slightly soluble in methanol, very slightly soluble in anhydrous ethanol, practically insoluble in acetone, in ethyl acetate and in methylene chloride.
• form: Solid
• color: White to Light yellow
• PH: pH (25g/l, 25℃) 3.0～4.5
• Water Solubility: Soluble in water (35mg/ml).
• Merck: 14,2314
• Major Application: pharmaceutical (small molecule)
• InChI: 1S/C17H18FN3O3.ClH.H2O/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;;/h7-10,19H,1-6H2,(H,23,24);1H;1H2
• InChIKey: DIOIOSKKIYDRIQ-UHFFFAOYSA-N
• SMILES: O.Cl.OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O
• CAS DataBase Reference: 86393-32-0(CAS DataBase Reference)

Safety Information

• WGK Germany: 3
• HazardClass: IRRITANT
• HS Code: 2933595960
• Storage Class: 11 - Combustible Solids

Ciprofloxacin hydrochloride hydrate Usage And Synthesis

Chemical Properties

Pale yellow, crystalline, slightly hygroscopic powder.

Uses

Ciprofloxacin hydrochloride has been suggested as a treatment for a wide range of infections caused by susceptible organisms including infections of urinary, respiratory, and gastrointestinal tracts, gonorrhoea and septicaemia. Nalidixic acid analogue.

Uses

Fluoroquinolone antibacterial.

Application

Ciprofloxacin hydrochloride hydrate is a broad-spectrum antibiotic that inhibits bacterial DNA gyrase and blocks DNA synthesis and replication, resulting in bacterial death. It has strong antibacterial activity against Escherichia coli, Klebsiella and other Enterobacteriaceae; the antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae is better than norfloxacin and pefloxacin.

Definition

ChEBI: The monohydrate form of ciprofloxacin monohydrochloride.

Brand name

Ciloxan (Alcon); Cipro (Bayer); Proquin (Esprit).

General Description

Ciprofloxacin HCl is a fluoroquinolone antibiotic agent, which shows a broad spectrum of antibacterial activity against gram positive and gram negative bacteria.

in vitro

Ciprofloxacin (hydrochloride monohydrate) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Ciprofloxacin (hydrochloride monohydrate) (CIP) shows potent activity against Y. pestis with MIC 90 of 0.03 μg/mL.

in vivo

Ciprofloxacin (hydrochloride monohydrate) (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin (hydrochloride monohydrate) (≥10 μg/L) is ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae. In a murine model of pneumonic plague, Ciprofloxacin (hydrochloride monohydrate) (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin (hydrochloride monohydrate). Intraperitoneal Ciprofloxacin (hydrochloride monohydrate) reduces the lung bacterial load compare to controls treated with intraperitoneal PBS.