Cyclopenthiazide CAS 742-20-1
Introduction：Basic information about Cyclopenthiazide CAS 742-20-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Cyclopenthiazide Basic information
| Product Name: | Cyclopenthiazide |
| Synonyms: | 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(cyclopentylmethyl)-3,4-dih;3-cyclopentylmethylhydrochlorothiazidederiv;cyclomethiazide;navidrix;salimed;salimid;su8341;tsiklometiazid |
| CAS: | 742-20-1 |
| MF: | C13H18ClN3O4S2 |
| MW: | 379.88 |
| EINECS: | 212-012-5 |
| Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Active Pharmaceutical Ingredients |
| Mol File: | 742-20-1.mol |
Cyclopenthiazide Chemical Properties
| Melting point | 230° |
| Boiling point | 605.6±65.0 °C(Predicted) |
| density | 1.3650 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | Refrigerator |
| solubility | Acetonitrile (Slightly), DMSO (Slightly), Methanol (Sparingly) |
| pka | 9.00±0.40(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | 50mg/L(room temperature) |
| Major Application | pharmaceutical pharmaceutical small molecule |
| InChI | 1S/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19) |
| InChIKey | BKYKPTRYDKTTJY-UHFFFAOYSA-N |
| SMILES | [S]1(=O)(=O)NC(Nc3c1cc(c(c3)Cl)[S](=O)(=O)N)CC2CCCC2 |
| CAS DataBase Reference | 742-20-1(CAS DataBase Reference) |
| EPA Substance Registry System | 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide (742-20-1) |
Safety Information
| WGK Germany | WGK 1 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Toxicity | LD50 in rats, mice (mg/kg): 141.8 ±24, 232.4 ±25 i.v. (Barrett) |
| Uses | Cyclopenthiazide is a thiazide diuretic. Cyclopenthiazide is used in the treatment of oedema caused by conditions such as kidney disease, liver cirrhosis and pre-menstrual syndrome as well as in the treatment of hypertension. |
| Uses | Antihypertensive;Sodium Chloride Symporter Inhibitor |
| Definition | ChEBI: 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide is a benzothiadiazine. |
| World Health Organization (WHO) | Cyclopenthiazide, a thiazide diuretic, was introduced in 1968. Itcontinues to be used mainly in combination drugs. |
| Clinical Use | Thiazide diuretic: Hypertension Heart failure Oedema |
| Drug interactions | Potentially hazardous interactions with other drugs Analgesics: increased risk of nephrotoxicity with NSAIDs; antagonism of diuretic effect. Anti-arrhythmics: hypokalaemia leads to increased cardiac toxicity; effects of lidocaine and mexiletine antagonised. Antibacterials: avoid administration with lymecycline. Antidepressants: increased risk of hypokalaemia with reboxetine; enhanced hypotensive effect with MAOIs; increased risk of postural hypotension with tricyclics. Antiepileptics: increased risk of hyponatraemia with carbamazepine. Antifungals: increased risk of hypokalaemia with amphotericin. Antihypertensives: enhanced hypotensive effect; increased risk of first dose hypotension with postsynaptic alpha-blockers like prazosin; hypokalaemia increases risk of ventricular arrhythmias with sotalol. Antipsychotics: hypokalaemia increases risk of ventricular arrhythmias with amisulpride; enhanced hypotensive effect with phenothiazines; hypokalaemia increases risk of ventricular arrhythmias with pimozide - avoid. Atomoxetine: hypokalaemia increases risk of ventricular arrhythmias. Cardiac glycosides: increased toxicity if hypokalaemia occurs. Ciclosporin: increased risk of nephrotoxicity and possibly hypomagnesaemia. Cytotoxics: increased risk of ventricular arrhythmias due to hypokalaemia with arsenic trioxide; increased risk of nephrotoxicity and ototoxicity with platinum compounds. Lithium: excretion reduced, increased toxicity |
| Metabolism | Cyclopenthiazide appears to be entirely excreted unchanged in the urine. |
Cyclopenthiazide Preparation Products And Raw materials
| Raw materials | Cyclopentyl Acetaldehyde |
