Introduction：Basic information about Difluoxacin hydrochloride CAS 91296-86-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Difluoxacin hydrochloride Basic informationBrand Name(s) in US
| Product Name: | Difluoxacin hydrochloride |
| Synonyms: | VETRANAL;6-FLUORO-1-(4-FLUOROPHENYL)-1,4-DIHYDRO-7-(4-METHYLPIPERAZINO)-4-OXO-3-QUINOLINECARBOXYLIC ACID HYDROCHLORIDE;DIFLUOXACIN HYDROCHLORIDE;DIFLOXACIN HCL;DIFLOXACIN HYDROCHLORIDE;Difluoxacin HCL;6-Fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid hydrochloride;3-Quinolinecarboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monohydrochloride |
| CAS: | 91296-86-5 |
| MF: | C21H20ClF2N3O3 |
| MW: | 435.85 |
| EINECS: | 1806241-263-5 |
| Product Categories: | DICURAL;Active Pharmaceutical Ingredients;Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API |
| Mol File: | 91296-86-5.mol |
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Difluoxacin hydrochloride Chemical Properties
| Melting point | >245°C (dec.) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in aqueous buffer |
| form | powder |
| color | White to off-white |
| Major Application | forensics and toxicology
pharmaceutical (small molecule) |
| InChI | InChI=1S/C21H19F2N3O3.ClH/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14;/h2-5,10-12H,6-9H2,1H3,(H,28,29);1H |
| InChIKey | JFMGBGLSDVIOHL-UHFFFAOYSA-N |
| SMILES | C12C=C(C(F)=CC=1C(C(C(=O)O)=CN2C1=CC=C(F)C=C1)=O)N1CCN(C)CC1.Cl |
| CAS DataBase Reference | 91296-86-5(CAS DataBase Reference) |
Safety Information
| WGK Germany | 3 |
| RTECS | VB2008975 |
| Storage Class | 11 - Combustible Solids |
Difluoxacin hydrochloride Usage And Synthesis
| Brand Name(s) in US | Dicural |
| Description | Difloxacin is a fluoroquinolone antibiotic. It is active against isolates of anaerobic bacteria, including B. fragilis, as well as Fusobacterium and Actinomyces species with MIC values ranging from ≤0.125 to 8 μg/ml. It eliminates E. coli and B. fragilis infection in a rat intra-abdominal abscess model when administered at a dose of 40 mg/kg three times per day. |
| Chemical Properties | Off-White to Pale Yellow Solid |
| Uses | antibacterial, DNA gyrase inhibitor |
| Uses | A quinolone antibacterial compound. Structurally related to norfloxacin |
| Uses | A fluoroquinolone antibacterial structurally related to norfloxacin. |
| References | [1] M B BANSAL H T. Activity of difloxacin (A-56619) and A-56620 against clinical anaerobic bacteria in vitro.[J]. Antimicrobial Agents and Chemotherapy, 1987, 31 4: 619-621. DOI: 10.1128/aac.31.4.619
[2] H THADEPALLI S K C S V Gollapudi. Therapeutic evaluation of difloxacin (A-56619) and A-56620 for experimentally induced Bacteroides fragilis-associated intra-abdominal abscess.[J]. Antimicrobial Agents and Chemotherapy, 1986, 30 4: 574-576. DOI: 10.1128/aac.30.4.574 |
Difluoxacin hydrochloride Preparation Products And Raw materials
