Introduction：Basic information about Diisopropylchlorosilane CAS 2227-29-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Diisopropylchlorosilane Basic information
| Product Name: | Diisopropylchlorosilane |
| Synonyms: | chloro(2,3-dimethylbutan-2-yl)silicon;Silane, chlorobis(1-methylethyl)-;CHLORODIISOPROPYLSILANE;DIISOPROPYLCHLOROSILANE;Diisopropylsilyl chloride;chloro-di(propan-2-yl)silicon;Chlorodiisopropylsilane >chlorobis(propan-2-yl)silane |
| CAS: | 2227-29-4 |
| MF: | C6H15ClSi |
| MW: | 150.72 |
| EINECS: | |
| Product Categories: | Pharmaceutical Intermediates;Monochlorosilanes;Reduction;Si (Classes of Silicon Compounds);Si-Cl Compounds;Si-H Compounds;Silicon Compounds (for Synthesis);Synthetic Organic Chemistry |
| Mol File: | 2227-29-4.mol |
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Diisopropylchlorosilane Chemical Properties
| Boiling point | 58-60 °C50 mm Hg(lit.) |
| density | 0.883 g/mL at 25 °C(lit.) |
| refractive index | n20/D 1.429(lit.) |
| Fp | 72 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | generally sol organic solvents; reacts with alcohols,ammonia,and water. |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Specific Gravity | 0.883 |
| Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
| BRN | 2231355 |
| InChI | InChI=1S/C6H15ClSi/c1-5(2)8(7)6(3)4/h5-6,8H,1-4H3 |
| InChIKey | CGXYLRTYLIHXEE-UHFFFAOYSA-N |
| SMILES | [SiH](Cl)(C(C)C)C(C)C |
| CAS DataBase Reference | 2227-29-4(CAS DataBase Reference) |
| EPA Substance Registry System | Silane, chlorobis(1-methylethyl)- (2227-29-4) |
Safety Information
| Hazard Codes | C |
| Risk Statements | 10-34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 2986 8/PG 2 |
| WGK Germany | 3 |
| F | 10-21 |
| TSCA | TSCA listed |
| HazardClass | 3.1 |
| PackingGroup | II |
| HS Code | 29319090 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Flam. Liq. 3
Skin Corr. 1B |
Diisopropylchlorosilane Usage And Synthesis
| Physical properties | bp 150–153°C,bp 54–55°C/45 mmHg;d 0.872 gmL?1 |
| Uses | Intramolecularhydrosilylation is also possible within β-diisopropylsilyloxyesters (13), constituting an exceptionally mild method for reducingester groups to the aldehyde oxidation level (eq 4).The derivatives(13) may be synthesized from β-hydroxy esters (12) as describedabove for the analogous ketones. Treatment with fluorideions (but not Lewis acids) induces hydride transfer to givealkoxysiladioxanes (14) in excellent yields (≥95%). Althoughusually performed in dichloromethane, the hydrosilylation mayalso be accomplished with ethyl acetate as solvent, providingstrong evidence for intramolecularity. |
| Application | Used in a silylation-reduction-allylation sequence of β-hydroxy esters to homoallylic-substituted 1,3-diols.Used in the silylation-hydrosilation-oxidation of allyl alcohols to 1,3-diols. Reaction carried out in diastereoselective manner. Reduces β-hydroxy ketones to anti-1,3 diols. |
| Preparation | obtained by reaction of trichlorosilane withisopropylmagnesium chloride;the original yield of 45% maybe raised to 70–80% by employing conc hydrochloric acid toquench the reaction. |
| Purification Methods | Impurities can be readily detected by 1H NMR. Purify it by fractional distillation [Gilman & Clark J Am Chem Soc 69 1499 1947, Allen et al. J Chem Soc 3668 1957]. |
Diisopropylchlorosilane Preparation Products And Raw materials
| Raw materials | DIISOPROPYLSILANE-->ISOPROPYLMAGNESIUM BROMIDE-->2-Chloropropane-->ISOPROPYLMAGNESIUM CHLORIDE |
| Preparation Products | DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE) |
