Dioctyl sulfosuccinate sodium salt CAS 577-11-7
Introduction：Basic information about Dioctyl sulfosuccinate sodium salt CAS 577-11-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Dioctyl sulfosuccinate sodium salt Basic information
| Product Name: | Dioctyl sulfosuccinate sodium salt |
| Synonyms: | AEROSOL OT;AEROSOL OTB;AEROSOL(R) OT;AEROSOL(R) OT-100;AEROSOL(TM) OT;1,4-bis(2-ethylhexyl)sodiumsulfosuccinate;Sulfosuccinic acid, dioctyl ester, sodium salt;DIETHYLHEXYL SODIUM SULFOSUCCINATE |
| CAS: | 577-11-7 |
| MF: | C20H37O7S.Na |
| MW: | 444.56 |
| EINECS: | 209-406-4 |
| Product Categories: | Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfonic/Sulfinic Acid Salts;Sulfur Compounds;ISOPTOHYOSCINE;Anionic Surfactants;Functional Materials;Sulfonate (Surfactants);Surfactants;Hair Care;Skin Care;577-11-7;hnw00001 |
| Mol File: | 577-11-7.mol |
Dioctyl sulfosuccinate sodium salt Chemical Properties
| Melting point | 173-179 °C(lit.) |
| Boiling point | 82.7°C |
| density | 1.1 |
| vapor pressure | 0Pa at 25℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | methanol: 0.1 M at 20 °C, clear, colorless |
| form | Waxy Solid |
| Specific Gravity | 1.005_PERCENT VOLATILE: 40 |
| color | White |
| Water Solubility | 1.5 g/100 mL (25 ºC) |
| Sensitive | Hygroscopic |
| λmax | λ: 260 nm Amax: 0.1 λ: 280 nm Amax: 0.05 |
| Merck | 14,3401 |
| BRN | 4117588 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Cosmetics Ingredients Functions | SURFACTANT - HYDROTROPE SURFACTANT - EMULSIFYING SURFACTANT - CLEANSING CLEANSING |
| Cosmetic Ingredient Review (CIR) | Dioctyl sulfosuccinate sodium salt (577-11-7) |
| InChI | 1S/C20H38O7S.Na/c1-5-9-11-16(7-3)14-26-19(21)13-18(28(23,24)25)20(22)27-15-17(8-4)12-10-6-2;/h16-18H,5-15H2,1-4H3,(H,23,24,25);/q;+1/p-1 |
| InChIKey | APSBXTVYXVQYAB-UHFFFAOYSA-M |
| SMILES | [Na+].CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)S([O-])(=O)=O |
| LogP | 1.998 at 20℃ |
| CAS DataBase Reference | 577-11-7(CAS DataBase Reference) |
| EPA Substance Registry System | Bis(2-ethylhexyl) sodium sulfosuccinate (577-11-7) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-38-41-36/37/38 |
| Safety Statements | 26-39-37/39-36 |
| WGK Germany | 2 |
| RTECS | WN0525000 |
| F | 3-10 |
| TSCA | TSCA listed |
| HS Code | 29171900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Dam. 1 Skin Irrit. 2 |
| Hazardous Substances Data | 577-11-7(Hazardous Substances Data) |
| Toxicity | LD50 oral in rat: 1900mg/kg |
| Chemical Properties | white solid, often supplied as an aqueous solution |
| Chemical Properties | Docusate sodium is a white or almost white, waxlike, bitter tasting,plastic solid with a characteristic octanol-like odor. It is hygroscopicand usually available in the form of pellets, flakes, or rolls of tissuethinmaterial. |
| Uses | dioctyl sodium sulfosuccinate is a mild surfactant used as a cleans ing agent. |
| Uses | Sodium salt of Docusate, used for the treatment of constipation, acting as a laxative or stool softener. Also used in the synthesis of electrospun fibres for tailored and controlled antibiotic drug release. |
| Uses | Forms reverse micelles in hydrocarbon solvents; Suitable for the solubilization of the major myelin transmembrane proteolipid |
| Uses | anticholinergic, treatment of motion sickness |
| Uses | Dioctyl sulfosuccinate sodium salt is a wetting and emulsifying agent that is slowly soluble in water, having a solubility of 1 g in 70 ml of water. It functions as a wetting agent in fumaric acid-containing powdered fruit drinks to help the acid dissolve in water. It is used as a stabilizing agent on gums at not more than 0.5% by weight of the gum. It is used as a flavor potentiator in canned milk where it improves and maintains the flavor of the sterilized milk during storage. It also functions as a processing aid in the manufacture of unrefined sugar. It is also termed sodium dioctylsulfosuccinate. |
| Definition | ChEBI: Sodium docusate is an organic sodium salt. |
| Production Methods | Maleic anhydride is treated with 2-ethylhexanol to produce dioctylmaleate, which is then reacted with sodium bisulfite. |
| Brand name | Colace (Roberts Pharmaceutical); Correctol Stool Softener Laxative (Schering-Plough HealthCare); Dialose (Johnson & Johnson-Merck Consumer); Doxinate (Hoechst-Roussel); D-S-S (Parke-Davis); Modane Soft (Savage); Molofac (Bristol-Myers Squibb). |
| General Description | Odorless colorless to white waxy solid. Sinks and mixes slowly with water. |
| Air & Water Reactions | Mixes slowly with water. |
| Reactivity Profile | Docusate sodium causes foaming and spreading of water. Assists in putting out fires by water. [USCG, 1999]. |
| Health Hazard | Liquid is strong irritant to eye and may irritate skin by removing natural oils. Ingestion causes diarrhea and intestinal bloating. |
| Fire Hazard | Behavior in Fire: Causes foaming and spreading of water. Assists in putting out fires by water. |
| Flammability and Explosibility | Non flammable |
| Pharmaceutical Applications | Docusate sodium and docusate salts are widely used as anionicsurfactants in pharmaceutical formulations. Docusate sodium ismainly used in capsule and direct-compression tablet formulationsto assist in wetting and dissolution. |
| Safety Profile | Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. A skin and severe eye irritant. See also ESTERS. When heated to decomposition it emits toxic fumes of SOxand Na2O. |
| Safety | Docusate salts are used in oral formulations as therapeutic agentsfor their fecal softening and laxative properties. As a laxative inadults, up to 500mg of docusate sodium is administered daily individed doses; in children over 6 months old, up to 75 mg in divideddoses is used. The quantity of docusate sodium used as an excipientin oral formulations should therefore be controlled to avoidunintended laxative effects. Adverse effects associated withdocusate sodium include diarrhea, nausea, vomiting, abdominalcramps, and skin rashes. As with the chronic use of laxatives, theexcessive use of docusate sodium may produce hypomagnesemia. Docusate salts are absorbed from the gastrointestinal tract andexcreted in bile; they may cause alteration of the gastrointestinalepithelium. The gastrointestinal or hepatic absorption of otherdrugs may also be affected by docusate salts, enhancing activity andpossibly toxicity. Docusate sodium should not be administered withmineral oil as it may increase the absorption of the oil. LD50 (mouse, IV): 0.06 g/kg LD50 (mouse, oral): 2.64 g/kg LD50 (rat, IP): 0.59 g/kg LD50 (rat, oral): 1.9 g/kg |
| Solubility in organics | Dioctyl sodium sulfosuccinate (DSS) is the dioctyl ester of sodium sulfosuccinate (bis-2-ethyl-hexyl sodium sulfosuccinate). It dissolves slowly in water; at 25°C to the extent of 1.5 gm/100cc; at 70°C, 5.5 gm/100cc. It dissolves in oils, hydrocarbons, fats and waxs by heating above 75°C and remains in solution when cooled to room temperature. At room temperature, it is readily soluble in most organic solvents, both polar and non-polar. soluble in carbon tetrachloride, petroleum ether, naphtha, xylene, dibutyl phthalate, liquid petroleum, acetone, alcohol, vegetable oils. |
| storage | Docusate sodium is stable in the solid state when stored at roomtemperature. Dilute aqueous solutions of docusate sodium betweenpH 1–10 are stable at room temperature. However, at very low pH(<1) and very high pH (>10) docusate sodium solutions are subjectto hydrolysis. The solid material is hygroscopic and should be stored in an airtight container in a cool, dry place. |
| Purification Methods | Dissolve it in MeOH and the inorganic salts which precipitate are filtered off. Water is added and the solution is extracted several times with hexane. The residue is evaporated to one-fifth its original volume, *benzene is added and azeotropic distillation is continued until no water remains. The solvent is evaporated. The white residual solid is crushed and dried in vacuo over P2O5 for 48hours [El Seoud & Fendler J Chem Soc, Faraday Trans 1 71 452 1975]. [Beilstein 4 IV 114.] It solubilises major myelin trans membrane proteolipids, and forms reverse micelles in hydrocarbon solvents. |
| Incompatibilities | Electrolytes, e.g. 3% sodium chloride, added to aqueous solutionsof docusate sodium can cause turbidity. However, docusatesodium possesses greater tolerance to calcium, magnesium, andother polyvalent ions than do some other surfactants. Docusatesodium is incompatible with acids at pH < 1 and with alkalis at pH> 10. |
| Regulatory Status | GRAS listed. Included in the FDA Inactive Ingredients Database(IM injections; oral capsules, suspensions, and tablets; also topicalformulations). Included in nonparenteral medicines licensed in theUK. Included in the Canadian List of Acceptable Non-medicinalIngredients. |
Dioctyl sulfosuccinate sodium salt Preparation Products And Raw materials
| Raw materials | Maleic anhydride-->Sodium metabisulfite-->1-Octanol-->2-Ethylhexanol-->DL-2-Octanol-->Diisooctyl maleate |
| Preparation Products | finishing agent for polyester fiber-->nerves calming toothpaste-->SOD anti-decrepitude healthy toothpaste-->pearly toothpaste |
