Introduction：Basic information about Ethyl Biscoumacetate CAS 548-00-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Ethyl Biscoumacetate Basic information
| Product Name: | Ethyl Biscoumacetate |
| Synonyms: | DI(4-oxi-cymarinyl-3);Pelentan;Trombarin;Trombil;Trombolysan;2,2-bis(2-hydroxy-4-keto-chromen-3-yl)acetic acid ethyl ester;ethyl 2,2-bis(2-hydroxy-4-oxochromen-3-yl)acetate;ethyl 2,2-bis(2-hydroxy-4-oxo-chromen-3-yl)ethanoate |
| CAS: | 548-00-5 |
| MF: | C22H16O8 |
| MW: | 408.36 |
| EINECS: | 208-940-5 |
| Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 548-00-5.mol |
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Ethyl Biscoumacetate Chemical Properties
| Melting point | 177-182° and mp 154-157° |
| Boiling point | 448.92°C (rough estimate) |
| density | 1.3259 (rough estimate) |
| refractive index | 1.4480 (estimate) |
| storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | pKa 7.5 (Uncertain) |
| color | White |
| Water Solubility | 54.31mg/L(temperature not stated) |
Safety Information
| RIDADR | 2811 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 in mice, rats (g/kg): 0.88, 0.26 orally; 0.32, 1.1 i.p. (Gruber) |
Ethyl Biscoumacetate Usage And Synthesis
| Chemical Properties | White, crystalline solid; odorless; bittertaste.Soluble in acetone and benzene; slightly soluble in alcohol and ether; insoluble in water. |
| Originator | Tromexan,Geigy,US,1950 |
| Uses | Anticoagulant. |
| Uses | Medicine (anticoagulant). |
| Definition | A synthetic derivative of bishydroxycoumarin. |
| Manufacturing Process | 7 g of benzotetronic acid are dissolved in 750 cc of water at boilingtemperature and there after 10.5 g of glyoxylic acid ethyl ester ethylalcoholate are added. After a short while the liquid becomes turbid andgradually a white deposit is separated. The deposit is filtrated and dried invacuo. The melting point is 172°C to 174°C; after recrystallization frommethyl alcohol 153°C to 154°C.
The crude product is dissolved in sodium lye, filtrated by means of animalcharcoal precipitated by means of hydrochloric acid, and recrystallized frommethyl alcohol. The melting point is 153°C to 154°C. |
| Therapeutic Function | Anticoagulant |
| Synthesis | Ethyl biscoumacetate, the ethyl ester of bis-(4-hydroxy-3-coumarinyl)-acetic acid (24.1.9), is synthesized analogously from 4-hydroxycoumarine,but using ethylglyoxylate, its semiacetal or glyoxylic acid instead of formaldehyde. |
Ethyl Biscoumacetate Preparation Products And Raw materials
| Raw materials | 4-Hydroxycoumarin |
