Ethyl cellulose CAS 9004-57-3
Introduction：Basic information about Ethyl cellulose CAS 9004-57-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Ethyl cellulose Basic information
| Product Name: | Ethyl cellulose |
| Synonyms: | ampacete/c;aquacoat;aquacoatecd30;aquacoatecd30fmc;cellulose,triethylether;celluloseethyl;nixone/c;spt50cps |
| CAS: | 9004-57-3 |
| MF: | C23H24N6O4 |
| MW: | 448.47446 |
| EINECS: | 618-384-9 |
| Product Categories: | Cellulose;Materials Science;Natural Polymers;Polymer Science;Polymers |
| Mol File: | 9004-57-3.mol |
Ethyl cellulose Chemical Properties
| Melting point | 240-255 °C |
| density | 1.14 g/mL at 25 °C (lit.) |
| refractive index | n |
| storage temp. | 2-8°C |
| solubility | esters, aromatic hydrocarbons, alcohols and ketones: soluble |
| form | powder |
| color | White to slightly yellow |
| Specific Gravity | 1.14 |
| Water Solubility | insoluble |
| Merck | 14,3781 |
| Dielectric constant | 2.8（Ambient） |
| Cosmetics Ingredients Functions | VISCOSITY CONTROLLING BINDING FILM FORMING |
| Cosmetic Ingredient Review (CIR) | Ethyl cellulose (9004-57-3) |
| InChI | InChI=1S/C23H24N6O4/c1-4-5-8-28(9-10-33-17(3)30)20-6-7-22(16(2)11-20)26-27-23-18(14-24)12-21(29(31)32)13-19(23)15-25/h6-7,11-13H,4-5,8-10H2,1-3H3/b27-26+ |
| InChIKey | ARSKJXYLLONUAJ-CYYJNZCTSA-N |
| SMILES | C(OCCN(CCCC)C1=CC=C(/N=N/C2=C(C#N)C=C([N+]([O-])=O)C=C2C#N)C(C)=C1)(=O)C |
| EPA Substance Registry System | Ethyl cellulose (9004-57-3) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 1 |
| RTECS | FJ5950500 |
| F | 3 |
| Autoignition Temperature | 698 °F |
| TSCA | TSCA listed |
| HS Code | 39129000 |
| Storage Class | 11 - Combustible Solids |
| Hazardous Substances Data | 9004-57-3(Hazardous Substances Data) |
| Chemical Properties | white to slightly yellowish powder |
| Chemical Properties | Ethylcellulose is a tasteless, free-flowing, white to light tan-coloredpowder. |
| Chemical Properties | Ethyl celluloses are low density polymers (1070–1180 kg.m–3) with solubilities depending on the degree of ethylation; usually commercial grade contains 44–48% ethoxyl functional groups. Solid masses of ethylcellulose exhibit low absorption of moisture, excellent dimensional stability and low temperature toughness and impact resistance. Chemically they are less resistant towards acids than cellulose esters but much more resistant to alkalis. They can be processed by injection molding. Because ethylcellulose is soluble in a wide variety of solvents, it provides a wide variety of varnish formulations. Benzylcelluloses yield plastics with excellent dielectric properties and chemical stability. |
| Uses | Used as a binder and filler in dry vitamin preparations, as a component of protective coatings for vitamin and mineral tablets, and as a fixative in flavoring compounds. It is a cellulose ether containing ethyoxy groups attached by an ether linkage and containing an anhydrous basis of not more than 2.6 ethoxy groups per anhydroglucose unit. |
| Uses | ethyl cellulose is a binder, film former, and thickener. It is used in suntan gels, creams, and lotions. This is the ethyl ether of cellulose. |
| Uses | Film-former in coatings, hot-melt adhesives and transfer inks and as a plastic coating for a variety of substrates. |
| Uses | In the manufacture of plastics and lacquers. Pharmaceutic aid (tablet binder). |
| Production Methods | Ethylcellulose is prepared by treating purified cellulose (sourcedfrom chemical-grade cotton linters and wood pulp) with an alkalinesolution, followed by ethylation of the alkali cellulose withchloroethane as shown below, where R represents the celluloseradical: RONa + C2H5Cl→ROC2H5+NaCl The manner in which the ethyl group is added to cellulose can bedescribed by the degree of substitution (DS). The DS designates theaverage number of hydroxyl positions on the anhydroglucose unitthat have been reacted with ethyl chloride. Since each anhydroglucoseunit of the cellulose molecule has three hydroxyl groups, themaximum value for DS is three. |
| Preparation | Ethyl cellulose is prepared by reacting cellulose with caustic to form caustic cellulose, which is then reacted with chloroethane to form ethyl cellulose. Plasticgrade material contains 44-48% ethoxyl. Although not as resistant as cellulose esters to acids, it is much more resistant to bases. An outstanding feature is its toughness at low temperatures. |
| Definition | ChEBI: Ethyl cellulose is a glycoside. |
| Brand name | Aquacoat ECD (FMC);Ethocel (Dow Chemical). |
| Pharmaceutical Applications | Ethylcellulose is widely used in oral and topical pharmaceuticalformulations. The main use of ethylcellulose in oral formulations is as ahydrophobic coating agent for tablets and granules.Ethylcellulosecoatings are used to modify the release of a drug, to maskan unpleasant taste, or to improve the stability of a formulation; forexample, where granules are coated with ethylcellulose to inhibitoxidation. Modified-release tablet formulations may also beproduced using ethylcellulose as a matrix former. Ethylcellulose, dissolved in an organic solvent or solventmixture, can be used on its own to produce water-insoluble films.Higher-viscosity ethylcellulose grades tend to produce stronger andmore durable films. Ethylcellulose films may be modified to altertheir solubility, by the addition of hypromellose or aplasticizer. An aqueous polymer dispersion (or latex) of ethylcellulose such as Aquacoat ECD (FMCBiopolymer) or Surelease (Colorcon) may also be used to produceethylcellulose films without the need for organic solvents.Drug release through ethylcellulose-coated dosage forms can becontrolled by diffusion through the film coating. This can be a slowprocess unless a large surface area (e.g. pellets or granules comparedwith tablets) is utilized. In those instances, aqueous ethylcellulosedispersions are generally used to coat granules or pellets.Ethylcellulose-coated beads and granules have also demonstratedthe ability to absorb pressure and hence protect the coating fromfracture during compression. High-viscosity grades of ethylcellulose are used in drug microencapsulation. Release of a drug from an ethylcellulose microcapsule is afunction of the microcapsule wall thickness and surface area. In tablet formulations, ethylcellulose may additionally beemployed as a binder, the ethylcellulose being blended dry or wetgranulatedwith a solvent such as ethanol (95%). Ethylcelluloseproduces hard tablets with low friability, although they maydemonstrate poor dissolution. Ethylcellulose has also been used as an agent for deliveringtherapeutic agents from oral (e.g. dental) appliances. In topical formulations, ethylcellulose is used as a thickeningagent in creams, lotions, or gels, provided an appropriate solvent isused. Ethylcellulose has been studied as a stabilizer foremulsions. Ethylcellulose is additionally used in cosmetics and foodproducts. |
| Safety Profile | Low toxicity by ingestion and skin contact. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes |
| Safety | Ethylcellulose is widely used in oral and topical pharmaceuticalformulations. It is also used in food products. Ethylcellulose is notmetabolized following oral consumption and is therefore anoncalorific substance. Because ethylcellulose is not metabolized itis not recommended for parenteral products; parenteral use may beharmful to the kidneys. Ethylcellulose is generally regarded as a nontoxic, nonallergenic,and nonirritating material. As ethylcellulose is not considered to be a health hazard, theWHO has not specified an acceptable daily intake. The highestreported level used in an oral product is 308.8 mg in an oralsustained release tablet. LD50 (rabbit, skin): >5 g/kg LD50 (rat, oral): >5 g/kg |
| storage | Ethylcellulose is a stable, slightly hygroscopic material. It ischemically resistant to alkalis, both dilute and concentrated, andto salt solutions, although it is more sensitive to acidic materialsthan are cellulose esters. Ethylcellulose is subject to oxidative degradation in the presenceof sunlight or UV light at elevated temperatures. This may beprevented by the use of antioxidant and chemical additives thatabsorb light in the 230–340nm range. Ethylcellulose should be stored at a temperature not exceeding32°C (90°F) in a dry area away from all sources of heat. It shouldnot be stored next to peroxides or other oxidizing agents. |
| Incompatibilities | Incompatible with paraffin wax and microcrystalline wax. |
| Regulatory Status | GRAS listed. Accepted for use as a food additive in Europe.Included in the FDA Inactive Ingredients Database (oral capsules,suspensions and tablets; topical emulsions and vaginal preparations).Included in nonparenteral medicines licensed in Europe.Included in the Canadian List of Acceptable Non-medicinalIngredients. |
Ethyl cellulose Preparation Products And Raw materials
| Raw materials | CHLOROETHANE-->Dehydrolyzing agent-->Microcrystalline cellulose |
| Preparation Products | Carbendazim-->PENTYL ETHER-->scavenger of fabric maculae |
