Ethyl diazoacetate CAS 623-73-4
Introduction：Basic information about Ethyl diazoacetate CAS 623-73-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Ethyl diazoacetate Basic informationSynthesis
| Product Name: | Ethyl diazoacetate |
| Synonyms: | Acetic acid, diazo-, ethyl ester;Daae;Diazoacetic acid ethyl ester;Diazoacetic ester;diazoaceticacid,ethylester;diazo-aceticaciethylester;diazoaceticester;Diazoessigsaeure-aethylester |
| CAS: | 623-73-4 |
| MF: | C4H6N2O2 |
| MW: | 114.1 |
| EINECS: | 210-810-8 |
| Product Categories: | Azo/Diazo Compounds;Building Blocks;Carboxylic;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Azo/Diazo Compounds;Nitrogen Compounds;Organic Building Blocks |
| Mol File: | 623-73-4.mol |
Ethyl diazoacetate Chemical Properties
| Melting point | -22 °C (lit.) |
| Boiling point | 140-141 °C/720 mmHg (lit.) |
| density | 1.085 g/mL at 25 °C (lit.) |
| refractive index | n |
| Fp | 115 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Soluble), Hexane (Slightly), Methanol (Slightly) |
| form | Oil |
| color | Light Yellow to Orange |
| Merck | 13,3021 |
| BRN | 107654 |
| InChI | InChI=1S/C4H6N2O2/c1-2-8-4(7)3-6-5/h3H,2H2,1H3 |
| InChIKey | YVPJCJLMRRTDMQ-UHFFFAOYSA-N |
| SMILES | C(=O)(OCC)C=[N+]=[N-] |
| NIST Chemistry Reference | Ethyl diazoacetate(623-73-4) |
Safety Information
| Hazard Codes | Xn,F |
| Risk Statements | 5-10-22-40-67-65-48/20-38-11-63 |
| Safety Statements | 36/37-62-16 |
| RIDADR | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| RTECS | AG5775000 |
| HazardClass | 3.2 |
| PackingGroup | III |
| HS Code | 29270000 |
| Storage Class | 5.2 - Organic peroxides and self-reacting hazardous materials |
| Hazard Classifications | Acute Tox. 4 Oral Carc. 2 Eye Irrit. 2 Flam. Liq. 3 Self-react. E Skin Irrit. 2 |
| Synthesis | Glycine ethyl ester hydrochloride can be dissolved in a buffer solution composed of acetic acid and sodium acetate, and then dichloroethane is added as a solvent, and sodium nitrite solution is added dropwise at 10 to 15 ° C. After the dropwise addition, continue stirring for 15min. The separated organic layer is a dichloroethane solution of ethyl diazoacetate. NH2CH2COOC2H5·HCl+NaNO2+HCl→N2CHCOOC2H5+NaCl+H2O |
| Chemical Properties | Liquid. |
| Uses | Reagent for ruthenium-catalyzed asymmetric cyclopropanation of alkenes.1 |
| Uses | New Diazoacetate Formulations |
| Hazard | Flammable liquid that explodes whenheated. |
| Safety Profile | Poison by ingestion and intravenous routes. Questionable carcinogen with experimental carcinogenic and tumorigenic data. Can explode. Explodes on contact with tris(dimethy1amino) antimony. When heated to decomposition it emits toxic fumes of NOx. See also ESTERS. |
| Purification Methods | It is a very volatile yellow oil with a strong pungent odour. EXPLOSIVE [distillation even under reduced pressure is dangerous and may result in an explosion — TAKE ALL THE NECESSARY PRECAUTIONS IF DISTILLATION IS TO BE CARRIED OUT]. It explodes in contact with conc H2SO4-trace acid causes rapid decomposition. It is slightly soluble in H2O, but is miscible with EtOH, *C6H6, pet ether and Et2O. To purify, dissolve it in Et2O [using CH2Cl2 instead of Et2O, protects the ester from acid], wash it with 10% aqueous Na2CO3, dry (MgSO4), filter and repeat as many times as possible until the Et2O layer loses its yellow colour, then remove the solvent below 20o (vacuum). Note that prolonged heating may lead to rapid decomposition and low yields. It can also be purified by steam distillation under reduced pressure but with considerable loss in yield. Place the residual oil in a brown bottle, keep below 10o, and use as soon as possible without distilling. For preparing esters usually the ethereal solution is used directly without purification. [Womack & Nelson Org Synth Coll Vol III 392 1955, UV: Miller & White J Am Chem Soc 79 5974 1957, Fieser 1 367 1967, Beilstein 3 IV 1495.] |
Ethyl diazoacetate Preparation Products And Raw materials
| Raw materials | Ethyl acetate-->Glycine ethyl ester hydrochloride-->Permethric acid-->Buffer solution, pH 1.00 (±0.01 at 25°C), No Color, Specpure, NIST Traceable |
| Preparation Products | Ethyl chrysanthemumate-->2,2-Dimethyl-3-(2-methylpropyl)cyclopropanecarboxylic acid p-(methoxymethyl)benzyl ester-->ethyl glycinate-->Ethyl glycolate-->Benzeneacetic acid, α-(hydroxymethylene)-, ethyl ester, (αZ)--->Heptanoic acid, 2-methyl-3-oxo-, ethyl ester-->2-Pentenedioic acid, diethyl ester, (Z)- (9CI)-->2-Oxiranecarboxylicacid, 3-(trichloromethyl)-, ethyl ester-->ETHYL 3-BUTYNOATE-->ETHYL 3-METHOXYPHENYLACETATE-->Ethyl 4-methoxycinnamate-->2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER-->Diethyl iminodiacetate-->ethyl 5-(hydroxymethyl)-1H-pyrazole-3-carboxylate |
