Introduction：Basic information about L-Histidine hydrochloride monohydrate CAS 5934-29-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
L-Histidine hydrochloride monohydrate Basic information
| Product Name: | L-Histidine hydrochloride monohydrate |
| Synonyms: | L-ALPHA-AMINO-4(OR 5)-IMIDAZOLEPROPIONIC ACID MONOHYDROCHLORIDE, MONOHYDRATE;L-ALPHA-AMINO-BETA-(4-IMIDAZOLYL)PROPIONIC ACID MONOHYDROCHLORIDE;L-HIS HCL H2O;L-HISTIDINE MONOHYDROCHLORIDE H2O;L-(+)-HISTIDINE HYDROCHLORIDE MONOHYDRATE;L-HISTIDINE HYDROCHLORIDE MONOHYDRATE;L-HISTIDINE MONOHYDROCHLORIDE MONOHYDRATE;L-HISTIDINE HCL H2O |
| CAS: | 5934-29-2 |
| MF: | C6H12ClN3O3 |
| MW: | 209.63 |
| EINECS: | 611-821-4 |
| Product Categories: | Amino Acid Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;L-Amino Acids;5934-29-2 |
| Mol File: | 5934-29-2.mol |
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L-Histidine hydrochloride monohydrate Chemical Properties
| Melting point | 254 °C (dec.)(lit.) |
| alpha | 9.9 º (c=11, 6 N HCl) |
| bulk density | 770kg/m3 |
| density | 1.49 g/cm3 |
| vapor pressure | <1 hPa (20 °C) |
| storage temp. | Store below +30°C. |
| solubility | H2O: 100 mg/mL |
| form | Solid |
| color | White |
| Odor | odorless |
| PH | 3.5-4.5 (100g/l, H2O, 20℃) |
| PH Range | 3 - 4 at 105 g/l at 25 °C |
| Optical Rotation | [α]20/D +9.5±0.5°, c = 5% in 5 M HCl |
| biological source | non-animal source |
| Water Solubility | 169.9 g/L (20 ºC) |
| Merck | 14,4720 |
| BRN | 4168261 |
| Cosmetics Ingredients Functions | SKIN CONDITIONING
HAIR CONDITIONING |
| Cosmetic Ingredient Review (CIR) | L-Histidine hydrochloride monohydrate (5934-29-2) |
| InChI | 1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1 |
| InChIKey | CMXXUDSWGMGYLZ-XRIGFGBMSA-N |
| SMILES | O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O |
| LogP | -3.32 at 25℃ |
| CAS DataBase Reference | 5934-29-2(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 22-24/25-36/37-26 |
| WGK Germany | 3 |
| RTECS | MS3119000 |
| F | 10 |
| TSCA | Yes |
| HS Code | 29332990 |
| Storage Class | 11 - Combustible Solids |
L-Histidine hydrochloride monohydrate Usage And Synthesis
| Chemical Properties | white crystals or cryst. or granular powder |
| Uses | L-Histidine is used in cell culture media formulations used in biomanufacturing. L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis. |
| Uses | L-Histidine monohydrochloride, non-animal, is used in cell culture media formulations used in biomanufacturing. The use of non-animal-sourced L-Histidine and other components avoids the risk of contaminating bioproducts with adventitious viruses. |
| Uses | L-Histidine Hydrochloride Monohydrate can be used as AhR activators to treat gluten-induced gastrointestinal diseases. It can also be used for hair coloring method. |
| General Description | Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove? Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC? portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines. |
| Biochem/physiol Actions | L-Histidine is biosynthesized from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. This essential amino acid can be degraded to glutamate by histidiase, urocanase and imidazolonepropionase; it is also the precursor of histamine by action of histidine decarboxylase. |
| Purification Methods | Crystallise the monohydrochloride from aqueous EtOH or 60% aqueous EtOH (m 259odec). Alternatively dissolve 10g in 50mL of H2O, decolourise with Norite, filter, evaporate it in a vacuum to a syrup, cool to room temperature, add 95% EtOH with stirring until slightly turbid, scratch the sides of the vessel until crystals form, then add slowly 40mL of EtOH and keep at 0o overnight, filter the solid off, wash it several times with EtOH and dry it in a vacuum. [Cox J Biol Chem 78 475 1929, Cox et al. J Biol Chem 81 73 1929, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1972, 2098 1961, Beilstein 25 II 407, 25 III/IV 4346.] |
L-Histidine hydrochloride monohydrate Preparation Products And Raw materials
| Raw materials | L-Lysine-->Soy bean Isoflavone Isoflavone 10-40%-->HEMOGLOBIN |
| Preparation Products | N-Boc-L-Histidine |
