Introduction：Basic information about L-Lysine dihydrochloride CAS 657-26-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
L-Lysine dihydrochloride Basic information
| Product Name: | L-Lysine dihydrochloride |
| Synonyms: | DL-sercine methyl ester hydrochloride;L-Lisine dihydrochloride;L-LYSINE DIHYDROCHLORIDE 99%;L-LYSINE 2HCL;Lysine dihydrochloride;L-Lysine-alpha-15N2HCl;L-Lysine-UL-13C62HCl;L-Lysine dihydrate |
| CAS: | 657-26-1 |
| MF: | C6H16Cl2N2O2 |
| MW: | 219.11 |
| EINECS: | 211-518-3 |
| Product Categories: | Lysine [Lys, K];Amino Acids and Derivatives;Amino hydrochloride;alpha-Amino Acids;Amino Acids;Biochemistry |
| Mol File: | 657-26-1.mol |
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L-Lysine dihydrochloride Chemical Properties
| Melting point | 200-206 °C(lit.) |
| alpha | 14 º (c=2, water 18 ºC) |
| refractive index | 15 ° (C=2, H2O) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Crystalline Powder |
| color | White to very light yellow |
| Water Solubility | Soluble in water (100 mg/ml). |
| Sensitive | Hygroscopic |
| Merck | 14,5636 |
| BRN | 4539715 |
| InChI | InChI=1/C6H14N2O2.2ClH/c7-4-2-1-3-5(8)6(9)10;;/h5H,1-4,7-8H2,(H,9,10);2*1H/t5-;;/s3 |
| InChIKey | JBBURJFZIMRPCZ-WHWWGIJDNA-N |
| SMILES | [C@@H](N)(C(=O)O)CCCCN.Cl.Cl |&1:0,r| |
| CAS DataBase Reference | 657-26-1(CAS DataBase Reference) |
| EPA Substance Registry System | Lysine dihydrochloride (657-26-1) |
| CAS Number Unlabeled | 657-26-1 |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-37/39-26 |
| WGK Germany | 3 |
| F | 3-10 |
| TSCA | TSCA listed |
| HS Code | 29224190 |
| Storage Class | 11 - Combustible Solids |
L-Lysine dihydrochloride Usage And Synthesis
| Chemical Properties | white to very light yellow crystalline powder |
| Uses | Synthesis of hyperbranched polylysine using the N-hydroxysuccinimide ester of L-lysine dihydrochloride as AB 2 building block. The histidine and lysine standards were prepared from L-histidine monohydro- chloride and L-lysine dihydrochloride respectively. L-Homocitrulline-The copper complex was prepared from L-lysine dihydrochloride in 80 to 86 per cent yields. |
| Biological Activity | L-Lysine is an essential proteinogenic α amino acid used in a wide range of applications including as a supplement in cell culture media; a substrate of enzymes such as L-lysine oxidase (EC 1.4.3.14); a component of poly-lysine polymers; and a substrate for oxidation and glycation mechanism studies. |
| Synthesis | L-lysine dihydrochloride is an organic intermediate that can be obtained from Boc-Lys-OH as a feedstock by removing the protective groups. HCl (4 M in dioxane, 2.5 mL, 10.0 mmol, 10.0 equiv) was added to a solution of Boc-Lys-OH (297 mg, 1.00 mmol) in MeOH (10 mL). The reaction mixture was stirred for 24 h at room temperature. The solvent was removed under vacuum. The residue was dried under high vacuum for 4 hours to obtain the product. |
| Purification Methods | Crystallise it from MeOH, in the presence of excess HCl, by adding diethyl ether. [Yoneya J Biochem (Tokyo) 38 343 1951, Kearley & Ingersoll J Am Chem Soc 73 5783 1951, Beilstein 4 IV 2717.] |
L-Lysine dihydrochloride Preparation Products And Raw materials
