N-(tert-Butoxycarbonyl)-L-alanine CAS 15761-38-3

Introduction：Basic information about N-(tert-Butoxycarbonyl)-L-alanine CAS 15761-38-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

N-(tert-Butoxycarbonyl)-L-alanine Basic information

• Product Name: N-(tert-Butoxycarbonyl)-L-alanine
• Synonyms: BOC-L-ALANINE;BOC-L-ALANINE-OH;BOC-L-ALA-OH;BOC-L-ALA;BOC-ALA;BOC-ALANINE;BOC-ALA-OH;H-ALPHA-T-BOC-L-ALANINE
• CAS: 15761-38-3
• MF: C8H15NO4
• MW: 189.21
• EINECS: 239-847-8
• Product Categories: Boc-Amino Acids;Amino Acids (N-Protected);Biochemistry;Boc-Amino acid series;Boc-Amino Acids and Derivative;Alanine [Ala, A];Protected Amino Acids;straight chain compounds;Naphthyridines;Amino Acids;Amino Acid Derivatives;PROTECTED AMINO ACID & PEPTIDES
• Mol File: 15761-38-3.mol

N-(tert-Butoxycarbonyl)-L-alanine Chemical Properties

• Melting point: 79-83 °C(lit.)
• alpha: -26 º (c=2, acetic acid)
• Boiling point: 324.46°C (rough estimate)
• density: 1.2321 (rough estimate)
• refractive index: -25.5 ° (C=2, AcOH)
• storage temp.: Sealed in dry,2-8°C
• solubility: DMSO, Methanol
• pka: 4.02±0.10(Predicted)
• form: Granular Powder
• color: White
• Optical Rotation: [α]20/D 25±1°, c = 2% in acetic acid
• BRN: 1726365
• Major Application: peptide synthesis
• InChI: InChI=1S/C8H15NO4/c1-5(6(10)11)9-7(12)13-8(2,3)4/h5H,1-4H3,(H,9,12)(H,10,11)/t5-/m0/s1
• InChIKey: QVHJQCGUWFKTSE-YFKPBYRVSA-N
• SMILES: C(O)(=O)[C@H](C)NC(OC(C)(C)C)=O
• CAS DataBase Reference: 15761-38-3(CAS DataBase Reference)
• EPA Substance Registry System: L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]- (15761-38-3)

Safety Information

• Hazard Codes: Xi,Xn
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 24/25-36-26
• WGK Germany: 3
• TSCA: TSCA listed
• HS Code: 2924 19 00
• HazardClass: IRRITANT
• Storage Class: 11 - Combustible Solids

N-(tert-Butoxycarbonyl)-L-alanine Usage And Synthesis

Chemical Properties

White to off-white microcrystalline powder

Uses

Boc-Ala-OH can be used:

• In the preparation of N-propargylalanine, a key precursor to generate N-(3-aryl)propylated alanine residues.
• In the resolution of racemic mixture of 3,3′-bis(benzyloxy)-1,1′-binaphthalene-2,2′-diol.
• In the one-pot synthesis of hybrid tripeptidomimetics containing both amide and imide functionalities.

reaction suitability

reaction type: Boc solid-phase peptide synthesis
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis

N-(tert-Butoxycarbonyl)-L-alanine Preparation Products And Raw materials

• Raw materials: 4-Mercaptophenol-->TERT-BUTYL 1,2,2,2-TETRACHLOROETHYL CARBONATE)-->BOC-ALA-OTBU-->BOC-L-ALANINE METHYL ESTER-->tert-Butanol-->L-Alanine-->tert-butyl azidoformate
• Preparation Products: CYCLO(-ALA-ALA)-->Carbamic acid, acetyl-, 1,1-dimethylethyl ester (9CI)-->(S)-4-Methyl-2,5-oxazolidonedione-->(S)-tert-Butyl 1-oxo-1-(2-(pyridin-2-yl)hydrazinyl)propan-2-ylcarbamate-->Carbamic acid, [2-[bis(phenylmethyl)amino]-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester, (S)- (9CI)-->Carbamic acid, N-[(1S)-2-(3-methoxyphenyl)-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester-->Carbamic acid, N-[(1S,2R)-2-hydroxy-2-(3-methoxyphenyl)-1-methylethyl]-, 1,1-dimethylethyl ester-->BOC-THIONOALA-1-(6-NITRO)BENZOTRIAZOLIDE-->Carbamic acid, N-[2-(methoxymethylamino)-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester