Introduction：Basic information about N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine CAS 309-88-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Table of Contents
- 1. N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Basic information
- 2. N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Chemical Properties
- 3. Safety Information
- 4. N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Usage And Synthesis
- 5. N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Preparation Products And Raw materials
N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Basic information
| Product Name: | N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine |
| Synonyms: | SHIKAWA'S REAGENT;N,N-DIETHYL-1,1,2,3,3,3-HEXAFLUOROPROPYLAMINE;Ishikawa's Reagent, 1-(Diethylamino)-1,1,2,3,3,3-hexafluoropropane;N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine, 40% solution in THF;Ishikawa;Ishikawa's Reagent, technical, 90%;Ishikawa Reagent;MEC-81 |
| CAS: | 309-88-6 |
| MF: | C7H11F6N |
| MW: | 223.16 |
| EINECS: | 628-698-8 |
| Product Categories: | Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Fluorination;Halogenation;Synthetic Organic Chemistry;Chemical Synthesis;Fluorination Reagents;Synthetic Reagents |
| Mol File: | 309-88-6.mol |
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N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Chemical Properties
| Boiling point | 56-57 °C (lit.) |
| density | 1.230 g/mL at 25 °C (lit.) |
| refractive index | 1.3460 |
| Fp | 56-57°C/58mm |
| storage temp. | Flammables area |
| solubility | soluble in Acetone,Ether |
| pka | 1.50±0.70(Predicted) |
| form | Liquid |
| color | Clear colorless to yellow |
| Specific Gravity | 1.230 |
| Merck | 14,5108 |
| InChI | 1S/C7H11F6N/c1-3-14(4-2)7(12,13)5(8)6(9,10)11/h5H,3-4H2,1-2H3 |
| InChIKey | BNTFCVMJHBNJAR-UHFFFAOYSA-N |
| SMILES | CCN(CC)C(F)(F)C(F)C(F)(F)F |
| CAS DataBase Reference | 309-88-6(CAS DataBase Reference) |
| EPA Substance Registry System | N,N-Diethyl-2H-perfluoropropanamine (309-88-6) |
Safety Information
| Hazard Codes | C |
| Risk Statements | 10-34 |
| Safety Statements | 16-26-36/37/39-45 |
| RIDADR | 3267 |
| WGK Germany | 3 |
| Hazard Note | Corrosive |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29211999 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Flam. Liq. 3
Skin Corr. 1B |
N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Usage And Synthesis
| Chemical Properties | Clear colorless to yellow liquid |
| Uses | Demonstrates utility in fluorination.7 |
| Uses | Fluorinating agent. |
| Uses | Reactant for:
- Friedel-Crafts type arylation of hydrofluorocarbons
- Microbial hydroxylation of antibiotics
- Electrochemical fluorination of trialkylamines and tetraalkylammonium salts
- Fluorination of pyrethroides
Reactant for synthesis of:
- γ-Hydroxy-α-fluoro-α-trifluoromethylcarboxamide
- Florfenicol and thiamphenicol
|
| General Description | GC analysis includes Et2NCF=CFCF3 (two isomers), both of which are active fluorinating agents. |
| Synthesis | N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine is prepared as follows: take 600-700 portions of dichloromethane, add 65-85 portions of diethylamine, lower the temperature to -5 ?? to -25 ??, pass 110 portions of -165 portions of hexafluoropropylene after the reaction for 1h. 165 portions of hexafluoropropylene, pass through the reaction after 1h, get fluoride reagent standby; the addition amount of diethylamine is preferably 75-80 portions, the addition amount of hexafluoropropylene is preferably 160-165 portions. |
N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Preparation Products And Raw materials
| Raw materials | 1-Propen-1-amine, N,N-diethyl-1,2,3,3,3-pentafluoro--->N,N-DIETHYL-2,3,3,3-TETRAFLUOROPROPIONAMIDE-->1,2-DIBROMOHEXAFLUOROPROPANE-->Diethylamine-->Hexafluoropropylene |
