Naltrexone hydrochloride CAS 16676-29-2
Introduction：Basic information about Naltrexone hydrochloride CAS 16676-29-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Naltrexone hydrochloride Basic information
| Product Name: | Naltrexone hydrochloride |
| Synonyms: | N-CYCLOPROPYLMETHYL-14-HYDROXYDI-HYDROMORPHINONE HYDROCHLORIDE;NALTREXONE HYDROCHLORIDE;(5alpha)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride;(5A)-17-(CYCLOPROPYLMETHYL)-4,5-EPOXY-3,14-DIHYDROMORPHINAN-6-ONE HYDROCHLORIDE;17-(cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-onehydroch;17-(cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-onhydr;17-(cyclopropylmethyl)-4,5-alpha-oxy-3,14-dihydoxy-morphinan-6-onhydrochlo;17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-morphinan-6-onhydrochlor |
| CAS: | 16676-29-2 |
| MF: | C20H24ClNO4 |
| MW: | 377.87 |
| EINECS: | 240-723-0 |
| Product Categories: | Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Antagonists;Opioids;Pharmacologicals;Enzyme Inhibitors;Enzyme Inhibitors by Type;Other;Opioid receptor and opioid-like receptor |
| Mol File: | 16676-29-2.mol |
Naltrexone hydrochloride Chemical Properties
| Melting point | 274-2760C |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL, clear, colorless |
| form | powder |
| color | White to Off-White |
| Water Solubility | Soluble in water at 50mg/ml. |
| Sensitive | Light Sensitive |
| Merck | 13,6389 |
| BRN | 3580333 |
| InChIKey | RHBRMCOKKKZVRY-LNTCFJBQNA-N |
| SMILES | O[C@]12CCC(=O)[C@]3([H])OC4=C(C=CC5C[C@@]1([H])N(CC1CC1)CC[C@@]23C4=5)O.Cl |&1:1,6,15,24,r| |
| CAS DataBase Reference | 16676-29-2(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 22-36 |
| WGK Germany | 3 |
| RTECS | QD2160000 |
| F | 8-10 |
| HS Code | 2932.99.7000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Toxicity | guinea pig,LD50,oral,1490mg/kg (1490mg/kg),Medicamentos de Actualidad. Vol. 21, Pg. 264, 1985. |
| Description | Naltrexone hydrochloride is a potent, long-acting, orally-effective narcoticantagonist useful in the management of narcotic addiction. |
| Chemical Properties | White Crystalline Powder |
| Originator | Endo (USA) |
| Uses | Nonselective opioid receptor antagonist; congener of naloxone |
| Uses | Naltrexone hydrochloride has been used: as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model. to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model. in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22. |
| Uses | sulfonamide, carbonic anhydrase inhibitor, anti-glaucoma agent |
| Uses | Narcotic antagonist, In treatment of?alcoholism |
| Definition | ChEBI: Naltrexone hydrochloride is a hydrochloride obtained by reaction of oxycodone with one molar equivalent of hydrochloric acid. it is a mu-opioid receptor antagonist that is used to treat alcohol dependence. It has a role as a mu-opioid receptor antagonist, an antidote to opioid poisoning and a central nervous system depressant. It contains a naltrexone(1+). |
| Brand name | TREXAN |
| Biological Activity | Opioid antagonist. |
| Biochem/physiol Actions | Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone. |
| Clinical Use | Opioid antagonist: Adjunctive prophylactic treatment in patient’s previously opioid dependant Treatment of alcohol dependence |
| Drug interactions | Potentially hazardous interactions with other drugs Opioids: Avoid concomitant use. |
| Metabolism | Naltrexone is well absorbed from the gastrointestinal tract but is subject to considerable first-pass metabolism and may undergo enterohepatic recycling. It is extensively metabolised in the liver and the major metabolite, 6-β-naltrexol, may also possess weak opioid antagonist activity.It is excreted mainly in the urine, <5% is excreted in the faeces.The renal clearance for naltrexone ranges from 30-127 mL/min and suggests that renal elimination is primarily by glomerular filtration |
| storage | Room temperature |
| Purification Methods | This narcotic antagonist has been purified by recrystallisation from MeOH and dried in air. The free base has m 168-170o after recrystallisation from Me2CO. [Cone et al. J Pharm Sci 64 618 1975, Gold et al. Med Res Rev 2 211 1982.] |
Naltrexone hydrochloride Preparation Products And Raw materials
| Preparation Products | Naltrexone 3-Methyl Ether-->NALTRINDOLE HYDROCHLORIDE |
