Introduction：Basic information about N-Isopropylbenzylamine CAS 102-97-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
N-Isopropylbenzylamine Basic information
| Product Name: | N-Isopropylbenzylamine |
| Synonyms: | Benzylamine, N-isopropyl-;Benzylisopropylamine;Isopropylbenzylamine;n-(1-methylethyl)-benzenemethanamin;N-ISOPROPYLBENZYLAMINE;N-BENZYLISOPROPYLAMINE;N-BENZYL-N-ISOPROPYLAMINE;n-(1-methylethyl)-benzenemethanamine |
| CAS: | 102-97-6 |
| MF: | C10H15N |
| MW: | 149.23 |
| EINECS: | 203-067-6 |
| Product Categories: | API;102-97-6;1 |
| Mol File: | 102-97-6.mol |
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N-Isopropylbenzylamine Chemical Properties
| Melting point | 143°C (estimate) |
| Boiling point | 200 °C(lit.) |
| density | 0.892 g/mL at 25 °C(lit.) |
| refractive index | n20/D 1.502(lit.) |
| Fp | 190 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Ethy Acetate (Slightly), Methanol (Slightly) |
| pka | 9.77±0.19(Predicted) |
| form | Oil |
| color | Colourless |
| BRN | 2638437 |
| InChI | 1S/C10H15N/c1-9(2)11-8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3 |
| InChIKey | LYBKPDDZTNUNNM-UHFFFAOYSA-N |
| SMILES | CC(C)NCc1ccccc1 |
| CAS DataBase Reference | 102-97-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzenemethanamine, N-(1-methylethyl)-(102-97-6) |
| EPA Substance Registry System | Benzenemethanamine, N-(1-methylethyl)- (102-97-6) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | 2735 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29214980 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
N-Isopropylbenzylamine Usage And Synthesis
| Chemical Properties | CLEAR VERY SLIGHTLY YELLOW TO YELLOW LIQUID |
| Uses | N-Isopropylbenzylamine, can be used as an intermediate in the synthesis of pharmaceutical compounds,and as a precursor to the manufacture of some drugs. Due to it’s similarity in appearance and physical properties to methamphetamine, it has been recently come under consideration of DEA. |
| Preparation | N-benzylisopropylamine is synthesized by the reduction reaction of N-isopropylbenzamide or prepared from benzylamine and acetone by reductive amination reaction. |
| Application | N-Isopropylbenzylamine was used as ligand in the preparation and characterization of bis(cyclopentadienyl)magnesium. It was also used in the synthesis of N-benzylideneisopropylamine-N-oxide. |
| General Description | N-isopropylbenzylamine is a structural isomer of methamphetamine, is one of the most common adulterants. It forms amine adducts with magnesocene at ambient temperature in toluene. |
| Cytotoxicity | The toxicity of N-isopropylbenzylamine was evaluated in SH-SY5Y, PC12, and SN4741 cell lines. Cells were treated with 0.3–10 mM N-isopropylbenzylamine for 24 hours, and cell viability was measured using MTT assay. N-isopropylbenzylamine concentration-dependently reduced cell viability in these cells. The IC50 values of N-isopropylbenzylamine on cell viability were 3.47, 1.49, and 3.21 mM for SH-SY5Y cells, PC12 cells, and SN4741 cells, respectively. N-isopropylbenzylamine produced toxicity in cell lines that model neurons. Moreover, the activation of nNOS and the production of intracellular NO might be involved in N-isopropylbenzylamine-induced toxicity in SN4741 cells[1]. |
| References | [1] Peng Xu . “N-isopropylbenzylamine, a methamphetamine mimics, produces toxicity via increasing nitric oxide in vitro.” Toxicology 480 (2022): Article 153337. |
N-Isopropylbenzylamine Preparation Products And Raw materials
| Raw materials | N-Ethylbenzylamine |
| Preparation Products | N-BENZYL-2-CHLORO-N-ISOPROPYL-ACETAMIDE |
