Oleyl alcohol CAS 143-28-2
Introduction：Basic information about Oleyl alcohol CAS 143-28-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Oleyl alcohol Basic information
| Product Name: | Oleyl alcohol |
| Synonyms: | unjecol50;unjecol70;unjecol90;Oleyl alcohol, ≥99% (GC);Oleyl alcohol, technical grade, 80-85%;Oleyl alcohol, ca. 60%, technical;Oleyl alcohol, 99+%;DELTA 9 OLEYL ALCOHOL |
| CAS: | 143-28-2 |
| MF: | C18H36O |
| MW: | 268.48 |
| EINECS: | 205-597-3 |
| Product Categories: | Acyclic;Alkenes;Biochemicals and Reagents;Building Blocks;Chemical Synthesis;Fatty Acids and conjugates;Biochemistry;Higher Fatty Acids & Higher Alcohols;Fatty Acyls;Fatty Alcohols;Lipids;Monoenoic fatty acids;Organic Building Blocks;Unsaturated Fatty Acids and Derivatives;Unsaturated Higher Alcohols |
| Mol File: | 143-28-2.mol |
Oleyl alcohol Chemical Properties
| Melting point | 0-5.0 °C (lit.) |
| Boiling point | 207 °C/13 mmHg (lit.) |
| density | 0.849 g/mL at 25 °C (lit.) |
| vapor pressure | 10.64 hPa (195 °C) |
| refractive index | n |
| FEMA | 4363 | CIS-9-OCTADECENOL |
| Fp | >230 °F |
| storage temp. | -20°C |
| solubility | Soluble in ethanol (95%), and ether; practicallyinsoluble in water. |
| pka | 15.20±0.10(Predicted) |
| form | Viscous Liquid |
| color | Clear almost colorless to yellow |
| Odor | fatty animal |
| Odor Type | fatty |
| Water Solubility | Miscible with alcohol and ether. Slightly miscible with carbon tetrachloride. Immiscible with water. |
| Merck | 14,6831 |
| JECFA Number | 1637 |
| BRN | 1723962 |
| Stability: | Stable. Combustible. Incompatible with strong acids, strong oxidizing agents. |
| Cosmetics Ingredients Functions | EMULSION STABILISING SKIN CONDITIONING - EMOLLIENT FRAGRANCE SOLVENT PERFUMING VISCOSITY CONTROLLING |
| Cosmetic Ingredient Review (CIR) | Oleyl alcohol (143-28-2) |
| InChI | 1S/C18H36O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19/h9-10,19H,2-8,11-18H2,1H3/b10-9- |
| InChIKey | ALSTYHKOOCGGFT-KTKRTIGZSA-N |
| SMILES | CCCCCCCC\C=C/CCCCCCCCO |
| LogP | 7.07 at 25℃ |
| CAS DataBase Reference | 143-28-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Oleyl Alcohol(143-28-2) |
| EPA Substance Registry System | 9-Octadecen-1-ol, (9Z)- (143-28-2) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 38 |
| Safety Statements | 26-36 |
| WGK Germany | - |
| RTECS | RG4120000 |
| TSCA | TSCA listed |
| HS Code | 29052990 |
| Storage Class | 10 - Combustible liquids |
| Hazardous Substances Data | 143-28-2(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
| Chemical Properties | Colourless or light yellow liquid. |
| Chemical Properties | Oleyl alcohol occurs as a pale yellow oily liquid that gives off acridfumes when heated. |
| Chemical Properties | Colorless to light yellow liquid; fatty aroma with animal undertones. |
| Uses | Oleyl alcohol is used in softening and lubrication of textile fabrics, and in the production of carbon paper, stencil paper, and printing ink. It finds application in cosmetic products viz skin creams and lotions as a thickner, hair conditioners and hair coating shampoos. It is utilized as an antifoaming agent and cutting lubricant, as the precursor for the preparation of its sulfuric ester derivatives, which are used in detergents and wetting agents. It plays a vital role in various formulations for drug delivery. |
| Uses | oleyl alcohol is an emollient, solvent, viscosity-increasing agent, and carrier employed in a wide variety of cosmetic formulations including makeup, skin care, and hand and body preparations. oleyl alcohol is an unsaturated fatty alcohol found in fish oils and can also be produced synthetically. According to some sources, it is comedogenic and has a mild irritancy potential. |
| Uses | Chiefly in the manufacture of its sulfuric esters which are detergents and wetting agents, as an antifoam agent; metal cutting lubricant; in carbon paper, stencil paper, printing ink; as a plasticizer; for softening and lubricating textile fabrics; carrier for medicaments. |
| Definition | ChEBI: A long chain fatty alcohol that is octadecanol containing a double bond located at position 9 (the Z-geoisomer). |
| Production Methods | Oleyl alcohol occurs naturally in fish oils. Synthetically, it can beprepared from butyl oleate by a Bouveault–Blanc reduction withsodium and butyl alcohol. An alternative method of manufacture isby the hydrogenation of triolein in the presence of zinc chromite. |
| Brand name | Witcohol 85 (Witco); Witcohol 90 (Witco). |
| Aroma threshold values | Fatty-type, medium strength odor. |
| General Description | Oleyl alcohol has been reported as an effective solvent for oil/water-type tacrolimus (FK506) cream formulation, useful for atopic dermatitis treatment. It was reported as diluting agent for Alamine 336. Palm oil esters derived from oleyl alcohol, have potential applications in the cosmetic and pharmaceutical industries due to the excellent wetting behavior of the esters without the oily feel. |
| Flammability and Explosibility | Non flammable |
| Pharmaceutical Applications | Oleyl alcohol is mainly used in topical pharmaceutical formulationsand has been used in transdermal delivery formulations.It hasbeen utilized in the development of biodegradable injectablethermoplastic oligomers,and in aerosol formulations of insulinand albuterol. Therapeutically, it has been suggested that oleyl alcohol mayexhibit antitumor properties via transmembrane permeation. |
| Safety Profile | A human skin and eye irritant. Aningredient in cosmetics. When heated to decomposition itemits acrid smoke and irritating fumes. |
| Safety | Oleyl alcohol is mainly used in topical pharmaceutical formulationsand is generally regarded as a nontoxic and nonirritant material atthe levels employed as an excipient. However, contact dermatitisdue to oleyl alcohol has been reported. The results of acute oral toxicity and percutaneous studies inanimals with products containing 8% oleyl alcohol indicate a verylow toxicity. Formulations containing 8% or 20% oleyl alcoholadministered by gastric intubation, at doses up to 10 g/kg bodyweight,caused no deaths and no toxic effects in rats. |
| storage | The bulk material should be stored in a well-closed container in acool, dry, place. |
| Purification Methods | Purify it by fractional crystallisation at -40o from acetone, then distil it under vacuum. [Beilstein 2 IV 2204.] |
| Regulatory Status | Included in the FDA Inactive Ingredients Database (topicalemulsions and ointments). Included in nonparenteral medicineslicensed in the UK. Included in the Canadian List of AcceptableNon-medicinal Ingredients. |
Oleyl alcohol Preparation Products And Raw materials
| Raw materials | Sodium-->Acetic anhydride-->Ethyl oleate-->9-Heptadecenoic acid, methyl ester, (9Z)- |
| Preparation Products | Methyl hexanoate-->polyoxyalkylene phosphate-->emulsifier VO series-->sodium (Z)-octadec-9-enyl sulphate-->TRANS-9-OCTADECENOL-->SELACHYL ALCOHOL-->11TR-EICOSENOIC ACID-->CIS-11-EICOSENOIC ACID METHYL ESTER-->METHYL TRANS-11-EICOSENOATE-->ERUCIC ACID METHYL ESTER-->1-Octadecanol-->Nonanoic acid |
