Introduction：Basic information about CAS 17355-10-1|Tyrosylleucine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tyrosylleucine |
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| CAS Number | 17355-10-1 | Molecular Weight | 294.35 |
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| Density | 1.218g/cm3 | Boiling Point | 575.9ºC at 760 mmHg |
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| Molecular Formula | C15H22N2O4 | Melting Point | / |
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| MSDS | / | Flash Point | 302.1ºC |
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Names
| Name | Tyr-Leu |
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| Synonym | More Synonyms |
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Tyrosylleucine BiologicalActivity
| Description | Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vivo | Tyrosylleucine (YL), administered orally, intracerebroventricularly, or intraperitoneally exhibits a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice[1]. Animal Model: Male ddY mice (24-27 g)[1] Dosage: 0.1-30 mg/kg, i.p.; 0.1-1.0 nmol/mouse, i.c.v.; 30-100 mg/kg, p.o. Administration: Administered orally, intracerebroventricularly, or intraperitoneally Result: Decreased immobility time after intraperitoneal (1-30 mg/kg) and intracerebroventricular (0.3-1 nmol/mouse) administrations in the FST. Exhibited a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice. |
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| References | [1]. Takafumi Mizushige, et al. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Sci Rep. 2020 Feb 10;10(1):2257. [2]. Norimasa Kanegawa, et al. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584(3):599-604. |
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Chemical & Physical Properties
| Density | 1.218g/cm3 |
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| Boiling Point | 575.9ºC at 760 mmHg |
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| Molecular Formula | C15H22N2O4 |
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| Molecular Weight | 294.35 |
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| Flash Point | 302.1ºC |
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| Exact Mass | 294.15800 |
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| PSA | 112.65000 |
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| LogP | 1.96870 |
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| Vapour Pressure | 4.2E-14mmHg at 25°C |
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| Index of Refraction | 1.565 |
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| InChIKey | AUEJLPRZGVVDNU-STQMWFEESA-N |
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| SMILES | CC(C)CC(NC(=O)C(N)Cc1ccc(O)cc1)C(=O)O |
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Safety Information
| WGK Germany | 3 |
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| HS Code | 2924299090 |
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Customs
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| N-L-Tyrosyl-L-leucin |
| TYR-LEU |
| L-Leucine,N-L-tyrosyl |
| N-L-tyrosyl-L-leucine |
| tyrosylleucine |
| L-Tyrosyl-L-leucine |
| L-Tyrosyl-L-leucin |
| H-TYR-LEU-OH |
| L-tyrosine-L-leucine |
| TYR-LEU CRYSTALLINE |
