Introduction：Basic information about CAS 504-96-1|Neophytadiene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Neophytadiene |
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| CAS Number | 504-96-1 | Molecular Weight | 278.51600 |
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| Density | 0.796g/cm3 | Boiling Point | 344.5ºC at 760mmHg |
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| Molecular Formula | C20H38 | Melting Point | / |
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| MSDS | / | Flash Point | 160.2ºC |
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Names
| Name | 7,11,15-trimethyl-3-methylidenehexadec-1-ene |
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| Synonym | More Synonyms |
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Neophytadiene BiologicalActivity
| Description | Neophytadiene is a diterpene found in Turbinaria ornate, with anti-inflammatory antioxidant and cardioprotective properties[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| In Vitro | Neophytadiene has cytotoxic on RAW 264.7 cells with an IC50 of 50 μM[1]. Neophytadiene (50-100 μM; 30 min) successfully inhibits the NO production level and downregulated inducible nitric oxide synthase (iNOS) production in LPS (1 μg/mL)-induced RAW264.7 cells[1]. Neophytadiene (25-100 μM; 22 hours) significantly inhibits the NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in LPS (1 μg/mL)-induced RAW264.7 cells[1]. |
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| In Vivo | Neophytadiene (50 mg/kg; p.o.) shows dose-dependent reduction in the alanine aminotransferase (ALT) level[1]. Neophytadiene (25-50 mg/kg; p.o.) significantly reduces LPS (10 mg/kg)-increased IL6 and 1L10 levels and in heart tissue[1]. Neophytadiene (25-50 mg/kg; p.o.) significantly reduces LPS (10 mg/kg)-increased PGE2mRNA expression in heart tissue[1]. Neophytadiene significantly inhibits LPS (10 mg/kg)-induced NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in vivo[1]. Animal Model: Adult male Sprague Dawley rats (6-8 weeks)[1] Dosage: 12 mg/kg, 25 mg/kg, 50 mg/kg Administration: Oral administration, daily, for 7 days Result: Decreased haemoglobin (HGB) level, ALT level, and heart tissue TNF-α, IL1β, NF-κB, iNOS, PI3k/AktandMAPK in LPS (10 mg/kg)-treat rats. |
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| References | [1]. Meenakshi Bhardwaj, et al. Neophytadiene from Turbinaria ornata Suppresses LPS-Induced Inflammatory Response in RAW 264.7 Macrophages and Sprague Dawley Rats. Inflammation. 2020 Jun;43(3):937-950. |
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Chemical & Physical Properties
| Density | 0.796g/cm3 |
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| Boiling Point | 344.5ºC at 760mmHg |
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| Molecular Formula | C20H38 |
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| Molecular Weight | 278.51600 |
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| Flash Point | 160.2ºC |
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| Exact Mass | 278.29700 |
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| LogP | 7.16770 |
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| Index of Refraction | 1.449 |
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| InChIKey | NIDGCIPAMWNKOA-UHFFFAOYSA-N |
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| SMILES | C=CC(=C)CCCC(C)CCCC(C)CCCC(C)C |
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| Storage condition | 20°C |
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Synonyms
| Neophytadien |
| 3-Methylene-7,11,15-trimethylhexadec-1-ene |
| 7,11,15-Trimethyl-3-methylene-1-hexadecene |
| 3-Methylen-7,11,15-trimethyl-hexadecen-(1) |
| 2,6,10-trimethyl-14-ethylene-14-pentadecene |
| neophytadiene |
| 2-(4,8,12-Trimethyltridecyl)buta-1,3-diene |
