Introduction：Basic information about CAS 882757-24-6|N,N'-[[5-[2-Amino-5-(2,2-dimethyl-1-oxopropyl)-4-thiazolyl]-2-furanyl]pho, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | N,N'-[[5-[2-Amino-5-(2,2-dimethyl-1-oxopropyl)-4-thiazolyl]-2-furanyl]phosphinylidene]bis[2-methylalanine] diethyl ester |
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| CAS Number | 882757-24-6 | Molecular Weight | 556.61 |
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| Density | 1.26 | Boiling Point | / |
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| Molecular Formula | C24H37N4O7PS | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | ethyl 2-[[[5-[2-amino-5-(2,2-dimethylpropanoyl)-1,3-thiazol-4-yl]furan-2-yl]-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)amino]phosphoryl]amino]-2-methylpropanoate |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | MB07803 is an orally available prodrug of a potent, noncompetitive inhibitor (MB07729) of fructose 1,6-bisphosphatase (FBPase), with EC50 of 140 nM and t1/2 of 7.6±2.9 h. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| Target | 31, 121, 189 nM for human, monkey, and rat, respectively [1] . |
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| References | [1]. van Poelje PD,et al. Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes. Handb Exp Pharmacol. 2011;(203):279-301. |
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Chemical & Physical Properties
| Density | 1.26 |
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| Molecular Formula | C24H37N4O7PS |
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| Molecular Weight | 556.61 |
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| PSA | 187.61000 |
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| LogP | 5.37690 |
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| InChIKey | CTKZZUXRWBCFEI-UHFFFAOYSA-N |
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| SMILES | CCOC(=O)C(C)(C)NP(=O)(NC(C)(C)C(=O)OCC)c1ccc(-c2nc(N)sc2C(=O)C(C)(C)C)o1 |
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Synonyms
| n,n'-((5-(2-amino-5-(2,2-dimethyl-1-oxopropyl)-4-thiazolyl)-2-furanyl)phosphinylidene)bis(2-methylalanine) diethyl ester |
| Alanine,N,N'-((5-(2-amino-5-(2,2-dimethyl-1-oxopropyl)-4-thiazolyl)-2-furanyl)phosphinylidene)bis(2-methyl-,diethyl ester |
| UNII-GG81XF45C2 |
