Introduction：Basic information about CAS 52468-60-7|Flunarizine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Flunarizine |
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| CAS Number | 52468-60-7 | Molecular Weight | 404.49500 |
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| Density | 1.17 g/cm3 | Boiling Point | 511.3ºC at 760 mmHg |
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| Molecular Formula | C26H26F2N2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Flunarizine |
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| Synonym | More Synonyms |
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Flunarizine BiologicalActivity
| Description | Flunarizine is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine is a D2 dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects[1][2][3][4][5]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelSignaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelSignaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
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| Target | D2 Receptor |
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| In Vitro | Flunarizine blocks sodium currents (INa) and calcium currents (ICa) with IC50 values of 0.94 μM and 1.77 μM in cultured rat cortical neurons, respectively[2]. Flunarizine (10 and 30 μM; 24 h) shows cytotoxic effects to chromaffin cells[4]. Flunarizine (1-30 μM) causes clear cytoprotection of chromaffin cell at concentrations of 3-10 μM[4]. Cell Cytotoxicity Assay[4] Cell Line: Chromaffin cells[4] Concentration: 10 and 30 μM Incubation Time: 24 hours Result: Showed a tendency to increase cell death at the concentration of 10 μM, and showed near 100% cell loss at the concentration of 30 μM. |
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| In Vivo | Flunarizine (intraperitoneal injection; 30 mg/kg; once) protects mice from lipopolysaccharide- (LPS-) induced acute lung injury (ALI)[5]. Animal Model: Male BALB/c mice (6-8 weeks old) with acute lung injury induced by lipopolysaccharide[5] Dosage: 30 mg/kg Administration: Intraperitoneal injection; 30 mg/kg; once Result: Suppressed the LPS-induced cell influx, protein leakage, and inflammatory cytokines release. Inhibited the pulmonary inflammation. |
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Chemical & Physical Properties
| Density | 1.17 g/cm3 |
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| Boiling Point | 511.3ºC at 760 mmHg |
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| Molecular Formula | C26H26F2N2 |
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| Molecular Weight | 404.49500 |
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| Exact Mass | 404.20600 |
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| PSA | 6.48000 |
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| LogP | 5.26100 |
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| Index of Refraction | 1.606 |
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| InChIKey | SMANXXCATUTDDT-QPJJXVBHSA-N |
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| SMILES | Fc1ccc(C(c2ccc(F)cc2)N2CCN(CC=Cc3ccccc3)CC2)cc1 |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TK9188600
- CHEMICAL NAME :
- Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl) -, (E)-
- CAS REGISTRY NUMBER :
- 52468-60-7
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C26-H26-F2-N2
- MOLECULAR WEIGHT :
- 404.54
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 4286 ug/kg/30D-I
- TOXIC EFFECTS :
- Behavioral - tremor
- REFERENCE :
- NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951- Volume(issue)/page/year: 37,881,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 18 mg/kg/90D-I
- TOXIC EFFECTS :
- Behavioral - tremor
- REFERENCE :
- NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951- Volume(issue)/page/year: 37,881,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 960 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,1103,1987
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Synonyms
| flunarazine |
| (E)-1-[bis(4-fluorophenyl)methyl]-4-(cinnamyl)piperazine |
| Sibelium |
| 1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine |
| 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]piperazine |
| EINECS 257-937-5 |
| (E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine |
| Fluarizine |
| (e)-piperazin |
| 1-[Bis(4-fluorophenyl)methyl]-4-[(E)-3-phenyl-2-propenyl]piperazine |
| 1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine |
| (e)-1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine |
| MFCD00242731 |
| Piperazine,1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-,(E) |
